Τίτλος:
Individual and combined assessment of ser680asn fsh receptor and fshβ-211 g>t gene polymorphisms in ovarian response in ivf/icsi program
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Molecular biology tools, such as the detection of Single Nucleotide Polymor-phisms (SNPs), have been considered to assist in the management of ovarian stimulation protocols. Purpose: The aim of this study was to evaluate the impact of two polymorphisms, the Asn680Ser pol-ymorphism of the FSHR gene, and the FSH β subunit (FSHβ) gene polymorphism-211 G>T, in a Greek population of women undergoing IVF/ICSI program in our center. In addition, a control group of fertile women was studied to verify whether there are differences in the genotype distribution between fertile and infertile population for both polymorphisms, as the FSHβ gene polymorphism-211 G>T is studied for the first time in the Greek population. Results: The FSH β-211 G>T polymorphism, studied for the first time in the infertile Greek popula-tion, appears to be quite rare. When studying the two polymorphisms separately, statistically signifi-cant differences were obtained that concerned the LH levels. Discussion: According to the combination analysis of the two polymorphisms by the number of al-leles, women with 2-3 polymorphic alleles needed more days of stimulation, but there were no differences in pregnancy rates. Conclusion: This molecular genetic study helps to elucidate whether the polygenic combination of the Asn680Ser and FSH β subunit-211 G>T gene polymorphisms is of additive value in the prediction of ovarian response to exogenous gonadotropins. © 2021 Bentham Science Publishers.
Συγγραφείς:
Anagnostou, E.
Kafkoutsou, A.
Mavrogianni, D.
Domali, E.
Dimitroulia, E.
Mathiopoulos, D.
Drakakis, P.
Loutradis, D.
Περιοδικό:
Current Pharmaceutical Biotechnology
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
buserelin; chorionic gonadotropin; estradiol; estrogen; follitropin; follitropin beta subunit; follitropin receptor; gonadorelin agonist; luteinizing hormone; Muellerian inhibiting factor; follitropin; follitropin beta subunit; follitropin receptor, adult; Article; chemiluminescent microparticle immunoassay; DNA polymorphism; electrochemiluminescence; electrochemiluminescence immunoassay; embryo transfer; enzyme linked immunosorbent assay; female; genetic polymorphism; genotype; human; in vitro fertilization; intracytoplasmic sperm injection; oocyte; oocyte maturation; ovary hyperstimulation; ovulation induction; pregnancy rate; genetics; intracytoplasmic sperm injection; pregnancy; single nucleotide polymorphism, Female; Follicle Stimulating Hormone; Follicle Stimulating Hormone, beta Subunit; Humans; Polymorphism, Single Nucleotide; Pregnancy; Receptors, FSH; Sperm Injections, Intracytoplasmic
DOI:
10.2174/1389201021666201029153518
