Τίτλος:
The expression of nrip1 and lcor in endometrioid endometrial cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The aim of the study was to analyze the expression of nuclear receptor interacting protein 1 (NRIP1) and its partner ligand-dependent nuclear receptor co-repressor (LCOR) in endometrioid endometrial cancer and to investigate their association with estrogen receptor (ER), progesterone receptor (PR), Ki-67, clinicopathological parameters and patient survival. Materials and Methods: Immunohistochemical evaluation was carried out to investigate the subcellular expression of NRIP1 and LCOR in endometrioid endometrial cancer samples. Statistical analysis was used to identify the correlations of NRIP1 and LCOR expression with clinicopathological variables and to estimate the survival rates. Results: Endometrial cancer tissues exhibited higher expression of NRIP1 and LCOR in comparison with the normal tissues. Cytoplasmic LCOR expression was positively associated with ER and PR expression, while cytoplasmic NRIP1 expression was positively associated with ER expression. Moreover, cytoplasmic expression of NRIP1 was positively associated with Ki-67. Conclusion: Our study demonstrated that high cytoplasmic expression of LCOR may predict a longer overall survival of patients with endometrioid endometrial cancer. Patients with tumors expressing low levels of LCOR showed a worse survival compared to those expressing high levels. © 2021 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
FLINDRIS, S.
KATSOULAS, N.
GOUSSIA, A.
LAZARIS, A.C.
NAVROZOGLOU, I.
PASCHOPOULOS, M.
THYMARA, I.
Περιοδικό:
In vivo (Athens, Greece)
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
estrogen receptor; Ki 67 antigen; ligand dependent nuclear receptor co repressor; progesterone receptor; receptor interacting protein 140; tumor protein; unclassified drug; estrogen receptor; LCOR protein, human; progesterone receptor; receptor interacting protein 140; repressor protein; tumor marker, adult; aged; Article; cancer patient; cancer surgery; cancer survival; cancer tissue; clinical feature; cohort analysis; correlational study; endometrioid carcinoma; endometrium cancer; female; human; human tissue; immunohistochemistry; major clinical study; protein expression; radical hysterectomy; survival rate; treatment outcome; endometrioid carcinoma; endometrium tumor; genetics; metabolism, Biomarkers, Tumor; Carcinoma, Endometrioid; Endometrial Neoplasms; Female; Humans; Nuclear Receptor Interacting Protein 1; Receptors, Estrogen; Receptors, Progesterone; Repressor Proteins
DOI:
10.21873/INVIVO.12545
