Τίτλος:
Poly(L-lactic acid)-co-poly(butylene adipate) new block copolymers for the preparation of drug-loaded long acting injectable microparticles
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The present study evaluates the use of newly synthesized poly(L-lactic acid)-co-poly(butylene adipate) (PLA/PBAd) block copolymers as microcarriers for the preparation of arip-iprazole (ARI)-loaded long acting injectable (LAI) formulations. The effect of various PLA to PBAd ratios (95/5, 90/10, 75/25 and 50/50 w/w) on the enzymatic hydrolysis of the copolymers showed increasing erosion rates by increasing the PBAd content, while cytotoxicity studies revealed non-toxicity for all prepared biomaterials. SEM images showed the formation of well-shaped, spherical MPs with a smooth exterior surface and no particle’s agglomeration, while DSC and pXRD data revealed that the presence of PBAd in the copolymers favors the amorphization of ARI. FTIR spectroscopy showed the formation of new ester bonds between the PLA and PBAd parts, while analysis of the MP formulations showed no molecular drug–polyester matrix interactions. In vitro dissolution studies suggested a highly tunable biphasic extended release, for up to 30 days, indicating the potential of the synthesized copolymers to act as promising LAI formulations, which will maintain a continuous therapeutic level for an extended time period. Lastly, several empirical and mechanistic models were also tested, with respect to their ability to fit the experimental release data. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Karava, V.
Siamidi, A.
Vlachou, M.
Christodoulou, E.
Bikiaris, N.D.
Zamboulis, A.
Kostoglou, M.
Gounari, E.
Barmpalexis, P.
Λέξεις-κλειδιά:
aripiprazole; aripiprazole microparticle; copolymer; nanoparticle; poly(l lactic acid) co poly(butylene adipate); unclassified drug, adipose derived mesenchymal stem cell; agglomeration; analytic method; Article; chemical procedures; controlled study; crystallization; cytotoxicity; differential scanning calorimetry; dispersity; drug delivery system; drug formulation; drug loading; drug release; drug solubility; encapsulation efficiency; enzymatic hydrolysis; esterification; Fourier transform infrared spectroscopy; glass transition temperature; human; human cell; human tissue; in vitro study; melting temperature; mesenchymal stem cell; molecular weight; MTT assay; particle size; physical chemistry; physical parameters; polycondensation; polymerization; powder X ray diffractometry; scanning electron microscopy; size exclusion chromatography
DOI:
10.3390/pharmaceutics13070930
