Τίτλος:
Impact of K-ras over-expression in laryngeal squamous cell carcinoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: Oncogene up-regulation combined with suppressor gene down-regulation is a crucial genetic combination that promotes cell neoplastic phenotype and progressively malignant transformation in solid malignancies, including laryngeal squamous cell carcinoma (LSCC). Among oncogenes, the Kirsten ras oncogene homolog (K-Ras) is involved in LSCC onset and progression. Patients and Methods: Sixty (n=60) primary LSCC tissue sections were analyzed by immunohistochemistry (IHC). Digital image analysis (DIA) was also implemented for measuring K-Ras protein expression levels. Results: High KRas protein expression levels were observed in 20/60 (33.3%) LSCC tissue sections, whereas the rest of the cases (n=40; 66.7%) demonstrated low expression. Overall K-Ras expression was borderline significantly associated to the grade of the examined malignancies (p=0.048), whereas no other strong statistical correlations were identified. A progressive K-Ras overexpression was observed in all grades of the examined cases. Conclusion: K-Ras over expression is correlated to a progressive dedifferentiation in LSCC. © 2021 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Papanikolaou, V.
Chrysovergis, A.
Mastronikolis, S.
Tsiambas, E.
Ragos, V.
Peschos, D.
Spyropoulou, D.
Pantos, P.
Niotis, A.
Mastronikolis, N.
Kyrodimos, E.
Περιοδικό:
In vivo (Athens, Greece)
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
antineoplastic agent, alcohol consumption; Article; cancer chemotherapy; cancer diagnosis; cancer grading; cancer radiotherapy; cancer staging; cancer tissue; carcinogenesis; clinical feature; descriptive research; digital technology; female; gene overexpression; human; human tissue; image analysis; immunohistochemistry; larynx; larynx squamous cell carcinoma; major clinical study; male; oncogene K ras; phenotype; primary tumor; smoking; tumor differentiation; tumor volume; gene expression regulation; genetics; head and neck tumor; larynx tumor; oncogene ras; squamous cell carcinoma, Carcinoma, Squamous Cell; Gene Expression Regulation, Neoplastic; Genes, ras; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Squamous Cell Carcinoma of Head and Neck
DOI:
10.21873/invivo.12418
