Τίτλος:
Precision medicine in idiopathic pulmonary fibrosis therapy: From translational research to patient-centered care
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible fibrotic chronic lung disease affecting predominantly older adults, with a history of smoking. The current model of disease natural course is that recurrent injury of the alveolar epithelium in the context of advanced aging/cellular senescence is followed by defective re-epithelialization and scar tissue formation. Currently, two drugs, nintedanib and pirfenidone, that modify disease progression have been approved worldwide for the treatment of IPF. However, despite treatment, patients with IPF are not cured, and eventually, disease advances in most treated patients. Enhancing biogenomic and metabolic research output, its translation into clinical precision and optimal service delivery through patient-centeredness are key elements to support effective IPF care. In this review, we summarize therapeutic options currently investigated for IPF based on the major pathogenetic pathways and molecular targets that drive pulmonary fibrosis. © 2021
Συγγραφείς:
Antoniou, K.M.
Tsitoura, E.
Vasarmidi, E.
Symvoulakis, E.K.
Aidinis, V.
Tzilas, V.
Tzouvelekis, A.
Bouros, D.
Περιοδικό:
Current Opinion in Pharmacology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
3 [4 (1h imidazol 1 ylmethyl)phenyl] 5 (2 methylpropyl)thiophene 2 [(n butyloxylcarbamate) sulphonamide] sodium; antifibrotic agent; bardoxolone methyl; bi 1015550; bms 986278; bms986278; cc 90001; danazol; glpg 1205; nd l 02; nd l02; pamrevlumab; pln 74809; rg6354; setanaxib; td139; unclassified drug; vay 736; ziritaxestat, bacterial load; cell metabolism; fibroblast; fibrosing alveolitis; holistic care; human; macrophage; mitochondrial respiration; pathogenesis; patient care; personalized medicine; priority journal; Review; telomere shortening; aged; fibrosis; patient care; translational research, Aged; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Patient-Centered Care; Precision Medicine; Translational Medical Research
DOI:
10.1016/j.coph.2020.12.007
