Περίληψη:
Idiopathic pregnancy complications pose a major threat to both maternal and fetal health worldwide. Numerous studies have implicated the role of the renin-angiotensin system (RAS) in the development of obstetric syndromes, since it is crucial for the uteroplacental function. A major RAS component is the angiotensin-converting enzyme (ACE), which hydrolyses angiotensin I to angiotensin II, and not only regulates arterial pressure, but also fibrinolytic activity, indirectly, through the expression of plasminogen activator inhibitor-1. A key functional polymorphism of the ACE gene is the insertion/deletion (I/D) polymorphism, which affects gene expression and product levels, and can therefore lead to high blood pressure and/or reduced fibrinolytic activity. These can cause major pregnancy complications, such as preeclampsia, recurrent pregnancy loss and preterm birth. This review discusses how the ACE I/D is associated with susceptibility towards pregnancy complications, on its own or in combination with other functional gene polymorphisms such, as the angiotensin II receptor type 1 (AT1R) A1166CC, angiotensin II receptor type 2 (AT2R) G1332A, plasminogen activator inhibitor-1 (PAI-1) 4G/5G, matrix metallopeptidase- 9 (MMP-9) C1562T, angiotensinogen (AGT) M235T, renin (REN) 83A/G, factor XIII (F13) Val34Leu and endothelial nitric oxide synthase (eNOS) 4a/b. © 2021 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Gintoni, I.
Adamopoulou, M.
Yapijakis, C.
Λέξεις-κλειδιά:
dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase, DNA polymorphism; female; gene frequency; genetic association; genetic susceptibility; human; indel mutation; pathogenesis; preeclampsia; pregnancy; pregnancy complication; premature labor; prematurity; recurrent abortion; renin angiotensin aldosterone system; Review; risk factor; genetic polymorphism; genetics; genotype; newborn; preeclampsia; prematurity; risk factor, Female; Genotype; Humans; Infant, Newborn; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Pre-Eclampsia; Pregnancy; Premature Birth; Renin-Angiotensin System; Risk Factors
