Τίτλος:
An up-to-date evaluation of darolutamide for the treatment of prostate cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: Currently, in prostate cancer, an increasing number of novel drugs are being used to delay its advancement to metastatic castration-resistant prostate cancer (mCRPC). Apalutamide, enzalutamide, and most recently, darolutamide (novel androgen receptor antagonists) have been approved for nonmetastatic castration-resistant prostate cancer (nmCRPC). Areas covered: The authors have evaluated darolutamide, covering all aspects of the clinical development, competence, and safety profile of the drug. Expert opinion: The unique structure of darolutamide is characterized by a high affinity for androgen receptors and detainment of antagonist activity in mutant isoforms of androgen receptors. In clinical practice, this is the main reason that makes darolutamide exceptional in terms of safety and efficacy compared to other drugs in this category. Darolutamide is considered to have the lowest probability for adverse events (AEs) compared to apalutamide and enzalutamide. Future studies, along with real-world clinical data are warranted to improve personalized treatment strategies as well as sequencing treatment between approved novel drugs. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Moussa, M.
Lazarou, L.
Dellis, A.
Abou Chakra, M.
Papatsoris, A.
Περιοδικό:
Expert Opinion on Pharmacotherapy
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
abiraterone acetate; apalutamide; darolutamide; enzalutamide; androgen receptor; androgen receptor antagonist; darolutamide; phenylthiohydantoin; pyrazole derivative, arthralgia; Article; backache; castration resistant prostate cancer; clinical effectiveness; clinical trial (topic); drug approval; drug metabolism; drug safety; drug screening; fatigue; human; castration resistant prostate cancer; comparative study; drug effect; male, Androgen Receptor Antagonists; Humans; Male; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Pyrazoles; Receptors, Androgen
DOI:
10.1080/14656566.2020.1845650
