Τίτλος:
Risk models and scores in patients with peripheral artery disease and chronic limb-threatening ischemia: A comprehensive review
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Peripheral artery disease (PAD) affects more than 200 million patients worldwide and chronic limbthreatening ischemia (CLTI) is the most advanced stage of PAD with very high morbidity and mortality rates. Cardiovascular medicine is trending towards a more personalized approach where each individual patient will be managed according to specific risk factors, disease characteristics, expectations related to their disease and individualized assessment of potential outcomes. For this reason, a number of risk models and scores have been developed during the last few years. Our aim in this comprehensive review article is to provide an overview of selected risk models and scores for patients with PAD and CLTI. Given that some of the published scores were of low quality (minimal discriminatory ability), we included scores that were already externally validated or scores that had promising initial findings. Available scoring systems were grouped in the five following categories according to their utility: i) scores that can detect asymptomatic patients who should be screened for PAD, ii) scores for assessment of functional status and quality of life in patients with PAD, iii) scores assessing risk for amputation and other major adverse limb events among patients with CLTI, iv) scores for the optimal revascularization strategy in each patient and scores predicting successful procedural outcomes; v) scores predicting short or long-term cardiovascular and limb related outcomes after either revascularization or at least angiographic assessment. Limitations of available scoring systems include development and validation in specific populations, lack of external validation (for some of them) and also lack of synchrony with current era endovascular technology. However, with further optimization of current scores and the development of new scores, the field of PAD and CLI can be transitioned to a personalized medicine approach. © 2021 Bentham Science Publishers.
Συγγραφείς:
Kokkinidis, D.G.
Katamreddy, A.
Giannopoulos, S.
Schizas, D.
Georgopoulos, S.
Liakakos, T.
Armstrong, E.J.
Bakoyiannis, C.
Περιοδικό:
Current Pharmaceutical Design
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
angiography; angioplasty; ankle brachial index; asymptomatic disease; bypass surgery; Bypass versus Angioplasty in Severe Ischemia of the Leg; chronic disease; chronic limb threatening ischemia; CLI Frailty Score; Comprehensive Risk Assessment for Bypass; Finnvasc Score; functional status; human; Infrapopliteal Chronic Total Occlusion Score; leg revascularization; limb amputation; limb ischemia; Lower Extremity Grading System; mass screening; measurement accuracy; outcome assessment; peripheral occlusive artery disease; personalized medicine; predictive value; prevalence; Project of Ex Vivo graft Engineering via Transfection III score; quality of life; receiver operating characteristic; Review; risk assessment; risk factor; scoring system; sensitivity and specificity; treatment outcome; walking difficulty; Walking Estimated Limitation Calculated by History score; Walking Impairment Questionnaire; Wound Characteristics Ischemia and Foot Infection score; wound healing; chronic disease; ischemia; limb salvage; peripheral occlusive artery disease; retrospective study, Chronic Disease; Humans; Ischemia; Limb Salvage; Peripheral Arterial Disease; Quality of Life; Retrospective Studies; Risk Factors; Treatment Outcome
DOI:
10.2174/1381612826666200530214459
