Τίτλος:
Optimal Blood Pressure Control Improves Left Ventricular Torsional Deformation and Vascular Function in Newly Diagnosed Hypertensives: a 3-Year Follow-up Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We investigated the effects of optimizing blood pressure control on cardiac deformation and vascular function. For this purpose, in 200 untreated patients with essential hypertension, we assessed at baseline as well as after 3 years of optimal blood pressure control: arterial stiffness and coronary microcirculatory function as well as longitudinal and torsional deformation parameters. Compared to baseline, after 3 years of optimal blood pressure control, there was an improvement of longitudinal strain, twisting as well as untwisting parameters of the left ventricle. In parallel, there was an improvement in coronary microcirculatory function, arterial stiffness, left ventricular mass, and ventricular-arterial interaction. The reduction of arterial stiffness was independently associated with the respective improvement of cardiac deformation markers and coronary flow reserve after adjusting for blood pressure improvement. Blood pressure optimization improves LV longitudinal and torsional mechanics in hypertensives in parallel with arterial stiffness, resulting in improved ventricular-arterial interaction and coronary flow reserve. Trial registration: ClinicalTrials.gov Identifier: NCT02346695 © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Συγγραφείς:
Tzortzis, S.
Ikonomidis, I.
Triantafyllidi, H.
Trivilou, P.
Pavlidis, G.
Katsanos, S.
Katogiannis, K.
Birba, D.
Thymis, J.
Makavos, G.
Varoudi, M.
Frogoudaki, A.
Vrettou, A.-R.
Vlastos, D.
Parissis, J.
Lekakis, J.
Περιοδικό:
Journal of Cardiovascular Translational Research
Λέξεις-κλειδιά:
amlodipine; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; calcium channel blocking agent; hydrochlorothiazide; ramipril; thiazide diuretic agent; antihypertensive agent, adult; arterial stiffness; Article; blood pressure regulation; cardiovascular function; cardiovascular parameters; controlled study; coronary artery blood flow; coronary flow reserve; essential hypertension; female; follow up; heart left ventricle; heart left ventricle mass; human; left ventricular torsional deformation; major clinical study; male; priority journal; pulse wave velocity; aged; blood pressure; diagnostic imaging; drug effect; heart left ventricle function; hypertension; microcirculation; middle aged; pathophysiology; time factor; torsion; treatment outcome, Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Female; Follow-Up Studies; Humans; Hypertension; Male; Microcirculation; Middle Aged; Time Factors; Torsion Abnormality; Treatment Outcome; Vascular Stiffness; Ventricular Dysfunction, Left; Ventricular Function, Left
DOI:
10.1007/s12265-019-09951-9
