Τίτλος:
The effects of ascorbic acid and U-74389G on renal ischemia-reperfusion injury in a rat model
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: U-74389G and ascorbic acid protect the cells from oxidation. This study aimed to depict their role in ischemia-reperfusion injury in a renal rat model. Materials and Methods: Sixty Wistars rats were randomized into six groups of 10 animals each. Group A Ischemia 30 min, reperfusion 60 min; Group B Ischemia 30 min, reperfusion 120 min; Group C Ischemia 30 min, ascorbic acid administration, reperfusion 60 min; Group D Ischemia 30 min, ascorbic acid administration, reperfusion 120 min; Group E Ischemia 30 min, U-74389G administration, reperfusion 60 min; Group F Ischemia 30 min, U-74389G administration, reperfusion 120 min. We then collected tissue and blood samples. Results: Histology and the significantly decreased malondialdehyde and tumor necrosis factor-α levels indicated that ascorbic acid was superior to U-74389G, at pre-defined time intervals. Conclusion: Ascorbic acid and U-74389G ameliorated renal damage induced by ischemia-reperfusion injury, suggesting a therapeutic effect. © 2020 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Zografos, C.G.
Chrysikos, D.
Pittaras, T.
Karampelias, V.
Chairakakis, A.
Galanos, A.
Sfiniadakis, I.
Felekouras, E.
Zografos, G.C.
Sideris, M.
Papadopoulou, K.
Papalois, A.E.
Περιοδικό:
In vivo (Athens, Greece)
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione; alanine aminotransferase; ascorbic acid; aspartate aminotransferase; creatinine; gamma glutamyltransferase; malonaldehyde; tumor necrosis factor; 21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione; antioxidant; ascorbic acid; pregnane derivative, alanine aminotransferase blood level; animal experiment; animal model; animal tissue; Article; aspartate aminotransferase blood level; blood sampling; controlled study; creatinine blood level; drug effect; enzyme linked immunosorbent assay; gamma glutamyl transferase blood level; histology; histopathology; kidney function; kidney injury; kidney ischemia; kidney tubule; male; nonhuman; rat; renal ischemia reperfusion injury; reperfusion; time to treatment; animal; disease model; reperfusion injury; Wistar rat, Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Pregnatrienes; Rats; Rats, Wistar; Reperfusion Injury
DOI:
10.21873/invivo.12063
