Τίτλος:
Identification of Patients at high risk for postsurgical hypoparathyroidism
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: Postsurgical hypoparathyroidism (PostHypo) is a common complication after total thyroidectomy. We studied the risk factors associated with PostHypo. Patients and Methods: The study included 109 women, (mean age: 50.7±10.75 years), who underwent total thyroidectomy for thyroid diseases. Results: Based on the development of biochemical hypocalcemia on the first postoperative day following total thyroidectomy, (cCa<8.4 mg/dl), 37 women developed PostHypo and 72 did not. Younger age, a lower preoperative corrected calcium and the presence of parathyroid glands in the specimens were related to the development of PostHypo. Of all patients, 51.4% had a vitamin D deficiency. A parathyroid hormone (PTH) value ≥9.4 pg/ml was 84.9% sensitive and 71.4% specific to predict PostHypo on the 1st postoperative day. A 50% reduction of the PTH value on the 1st postoperative day from the preoperative level could identify patients who develop PostHypo with 76% sensitivity and 75% specificity. Conclusion: PTH postoperative measurement and its alteration from the preoperative level can be used to identify patients who are at increased risk to develop PostHypo. © 2020 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Kakava, K.
Tournis, S.
Makris, K.
Papadakis, G.
Kassi, E.
Dontas, I.
Karatzas, T.
Περιοδικό:
In vivo (Athens, Greece)
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
calcium; parathyroid hormone; calcium; parathyroid hormone, adult; Article; clinical observation; controlled study; female; high risk patient; human; human tissue; hypocalcemia; hypoparathyroidism; major clinical study; middle aged; parathyroid gland; postoperative complication; preoperative period; risk assessment; sensitivity and specificity; surgical risk; thyroid disease; thyroidectomy; vitamin D deficiency; adverse event; hypocalcemia; hypoparathyroidism; postoperative complication; thyroidectomy, Adult; Calcium; Female; Humans; Hypocalcemia; Hypoparathyroidism; Middle Aged; Parathyroid Hormone; Postoperative Complications; Thyroidectomy
DOI:
10.21873/invivo.12128
