Τίτλος:
Cytotoxicity and anti-cancer activity of the genus achillea L.
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The genus Achillea L. is rich in bioactive sesquiterpenes and fla-vonoids; most of the studied species exhibit several biological activities and are used as emmenagogue, wound healing and analgesic agents. Some species are also used in local folklore medicine. Objective: Following a literature survey, we discuss the anti-cancer properties of Achillea species, taking into consideration ethnopharmacological data on their use in traditional medicine for the treatment of cancer. In addition, we screened extracts and isolated secondary metabolites from A. coarctata for cytotoxicity, upon information based on local traditional medicine. The plant was collected in Kozani (Northern Greece), where it is locally used for treating gastrointestinal disorders, including stomach cancer. Method: A selection of the relevant data was performed through a search in PubMed, Sco-pus, Google Scholar and Science Direct databases. In addition, extracts and isolated compounds from A. coarctata were tested for their in vitro activity against the human cancer cell lines MCF-7 and HeLa. Conclusion: The genus Achillea L. is a valuable source of bioactive secondary metabolites. The most significant outcome of the investigation of medicinal plants is the documentation and the assessment of the traditional information and its use and perspectives in the light of modern pharmacology. © 2020 Bentham Science Publishers.
Συγγραφείς:
Papakosta, K.
Grafakou, M.-E.
Barda, C.
Kostopoulos, I.V.
Tsitsilonis, O.
Skaltsa, H.
Περιοδικό:
Current Medicinal Chemistry
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
Achillea coarctata extract; cytotoxic agent; doxorubicin; phytochemical; unclassified drug; antineoplastic agent; plant extract, Achillea; Achillea coarctata; antineoplastic activity; drug isolation; drug screening; ethnopharmacology; gastrointestinal disease; genus; Greece; HeLa cell line; human; IC50; in vitro study; malignant neoplasm; MCF-7 cell line; nonhuman; Review; stomach cancer; traditional medicine; Achillea; chemistry; medicinal plant; phytotherapy; secondary metabolism, Achillea; Antineoplastic Agents, Phytogenic; Ethnopharmacology; Greece; HeLa Cells; Humans; MCF-7 Cells; Medicine, Traditional; Phytotherapy; Plant Extracts; Plants, Medicinal; Secondary Metabolism
DOI:
10.2174/0929867327666200505092514
