Τίτλος:
Halogenated diterpenes with in vitro antitumor activity from the red alga sphaerococcus coronopifolius
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Eight new (1-8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC50 values 15 and 16 μM, respectively. © 2019 by the authors.
Συγγραφείς:
Smyrniotopoulos, V.
De Andrade Tomaz, A.C.
De Fátima Vanderlei De Souza, M.
Da Cunha, E.V.L.
Kiss, R.
Mathieu, V.
Ioannou, E.
Roussis, V.
Λέξεις-κλειδιά:
1 methoxy ioniol I; 8 methoxy dihydro sphaerococcenol; algal extract; antineoplastic agent; bromocoronol; bromotetrasphaereniol; debromosphaerol; diterpene; doxorubicin; iodocoronol; iso bromocorodienol; Sphaerococcus coronopifolius extract; unclassified drug; antineoplastic agent; biological product; diterpenoid, animal cell; antineoplastic activity; Article; carbon nuclear magnetic resonance; cell growth; colorimetry; controlled study; Greece; human; human cell; IC50; in vitro study; infrared spectroscopy; mouse; MTT assay; nonhuman; proton nuclear magnetic resonance; red alga; Sphaerococcus coronopifolius; thin layer chromatography; traditional medicine; ultraviolet spectroscopy; animal; chemistry; isolation and purification; neoplasm; nuclear magnetic resonance spectroscopy; pathology; tumor cell line, Animals; Antineoplastic Agents; Biological Products; Cell Line, Tumor; Diterpenes; Greece; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mice; Neoplasms; Rhodophyta
