Τίτλος:
Endothelin receptors in the brain modulate autonomic responses and arrhythmogenesis during acute myocardial infarction in rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aims: Endothelin has been implicated in various processes in the brain, including the modulation of sympathetic responses. The present study examined the pathophysiologic role of brain endothelin-receptors in the setting of acute myocardial infarction, characterized by high incidence of ventricular tachyarrhythmias. Main methods: We investigated the effects of intracerebroventricular administration of antagonists of endothelin-receptors ETA, ETB, or both, during a 24 h-observation period post-coronary ligation in (n = 70) rats. Continuous recording was performed via implanted telemetry transmitters, followed by arrhythmia-analysis and calculation of autonomic indices derived from heart rate variability. The regional myocardial electrophysiologic properties were assessed by monophasic action potentials and multi-electrode recordings. Key findings: Sympathetic-activity was decreased and vagal-activity was enhanced after intracerebroventricular ETA-receptor blockade, thus attenuating regional myocardial repolarization inhomogeneity. As a result, the incidence of ventricular tachyarrhythmias was markedly lower in this group. Such effects were also observed after intracerebroventricular blockade of ETB-, or both, ETA- and ETB-receptors, although to a lesser extent. Significance: ETA-receptors in the brain modulate sympathetic and vagal responses and alter arrhythmogenesis during evolving myocardial necrosis in rats. These findings provide insights into arrhythmogenic mechanisms during acute myocardial infarction and call for further investigation on the role of endothelin in the central autonomic network. © 2019
Συγγραφείς:
Lekkas, P.
Kontonika, M.
Georgiou, E.S.
La Rocca, V.
Mouchtouri, E.-T.
Mourouzis, I.
Pantos, C.
Kolettis, T.M.
Περιοδικό:
Life Science Leader
Εκδότης:
ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Λέξεις-κλειδιά:
cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl); endothelin receptor; n (2,6 dimethylpiperidinocarbonyl) 4 methylleucyl dextro (1 methoxycarbonyltryptophanyl) dextro norleucine; endothelin; endothelin 1; endothelin A receptor; endothelin B receptor; endothelin receptor; endothelin receptor antagonist, action potential; acute heart infarction; animal experiment; animal model; animal tissue; arrhythmogenesis; Article; autonomic nervous system; brain function; clinical effectiveness; controlled study; drug effect; drug efficacy; drug mechanism; drug response; heart electrophysiology; heart infarction size; heart rate variability; heart ventricle tachycardia; incidence; male; nonhuman; rat; Wistar rat; adrenergic system; animal; autonomic nervous system; brain; cardiac muscle; complication; heart arrhythmia; heart infarction; heart rate; metabolism; pathophysiology; physiology, Action Potentials; Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Brain; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Heart Rate; Male; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sympathetic Nervous System; Tachycardia, Ventricular
DOI:
10.1016/j.lfs.2019.117062
