Τίτλος:
The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of the main challenges in oral drug administration. Whereas pharmacokinetic (PK) food-drug interactions can have a variety of causes, pharmacodynamic (PD) food-drug interactions occur due to specific pharmacological interactions between a drug and particular drinks or food. In recent years, extensive efforts were made to elucidate the mechanisms that drive pharmacokinetic food-drug interactions. Their occurrence depends mainly on the properties of the drug substance, the formulation and a multitude of physiological factors. Every intake of food or drink changes the physiological conditions in the human gastrointestinal tract. Therefore, a precise understanding of how different foods and drinks affect the processes of drug absorption, distribution, metabolism and/or elimination as well as formulation performance is important in order to be able to predict and avoid such interactions. Furthermore, it must be considered that beverages such as milk, grapefruit juice and alcohol can also lead to specific food-drug interactions. In this regard, the growing use of food supplements and functional food requires urgent attention in oral pharmacotherapy. Recently, a new consortium in Understanding Gastrointestinal Absorption-related Processes (UNGAP) was established through COST, a funding organisation of the European Union supporting translational research across Europe. In this review of the UNGAP Working group “Food-Drug Interface”, the different mechanisms that can lead to pharmacokinetic food-drug interactions are discussed and summarised from different expert perspectives. © 2019 The Authors
Συγγραφείς:
Koziolek, M.
Alcaro, S.
Augustijns, P.
Basit, A.W.
Grimm, M.
Hens, B.
Hoad, C.L.
Jedamzik, P.
Madla, C.M.
Maliepaard, M.
Marciani, L.
Maruca, A.
Parrott, N.
Pávek, P.
Porter, C.J.H.
Reppas, C.
van Riet-Nales, D.
Rubbens, J.
Statelova, M.
Trevaskis, N.L.
Valentová, K.
Vertzoni, M.
Čepo, D.V.
Corsetti, M.
Περιοδικό:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Λέξεις-κλειδιά:
ABC transporter subfamily B; alcohol; carrier proteins and binding proteins; oligopeptide transporter; organic anion transporter; organosulfur derivative; polyphenol derivative; polysaccharide sulfate; probiotic agent; unclassified drug, alcoholic beverage; Article; bioequivalence; dietary supplement; drug absorption; drug bioavailability; drug delivery system; drug distribution; drug efficacy; drug elimination; drug formulation; drug mechanism; drug metabolism; drug protein binding; drug release; drug safety; drug solubility; drug transport; food drug interaction; functional food; gastrointestinal tract; grapefruit juice; human; intestine; intestine flora; intestine fluid; intestine motility; membrane fluidity; milk; pH; plasma protein binding; priority journal; stomach; stomach emptying; bioavailability; Europe; food drug interaction; gastrointestinal absorption; intestine absorption; oral drug administration; pharmacokinetics; physiology, Administration, Oral; Biological Availability; Drug Liberation; Europe; Food-Drug Interactions; Gastrointestinal Absorption; Gastrointestinal Tract; Humans; Intestinal Absorption; Pharmacokinetics
DOI:
10.1016/j.ejps.2019.04.003
