Τίτλος:
Synthesis of diphenoxyadamantane alkylamines with pharmacological interest
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia–f and IIa–f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity. © 2019 Elsevier Ltd
Συγγραφείς:
Georgiadis, M.-O.
Kourbeli, V.
Ioannidou, V.
Karakitsios, E.
Papanastasiou, I.
Tsotinis, A.
Komiotis, D.
Vocat, A.
Cole, S.T.
Taylor, M.C.
Kelly, J.M.
Περιοδικό:
Bioorganic and Medicinal Chemistry Letters
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
aliphatic amine; antitrypanosomal agent; diphenoxyadamantane alkylamine; tuberculostatic agent; unclassified drug; adamantane; amine; antitrypanosomal agent; tuberculostatic agent, antibacterial activity; Article; bacterial growth; controlled study; drug structure; drug synthesis; growth inhibition; Mycobacterium tuberculosis; nonhuman; trypanocidal activity; Trypanosoma brucei; chemical structure; chemistry; dose response; drug effect; drug sensitivity; structure activity relation; synthesis; Trypanosoma brucei brucei, Adamantane; Amines; Antitubercular Agents; Dose-Response Relationship, Drug; Molecular Structure; Mycobacterium tuberculosis; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei
DOI:
10.1016/j.bmcl.2019.04.010
