Τίτλος:
Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998-2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
El-Demerdash, A.
Atanasov, A.G.
Horbanczuk, O.K.
Tammam, M.A.
Abdel-Mogib, M.
Hooper, J.N.A.
Sekeroglu, N.
Al-Mourabit, A.
Kijjoa, A.
Λέξεις-κλειδιά:
aaptamine; antiinfective agent; antimalarial agent; antioxidant; bromotyrosine derivative; cholinesterase inhibitor; cytotoxic agent; isopernoid derivative; isoxazoline derivative; macrolide; natural product; oxepinisoxazoline derivative; phenol derivative; protein tyrosine kinase inhibitor; pyrrole derivative; sesterterpenoid derivative; tyrosine derivative; unclassified drug; biological product, biogenesis; biological activity; drug structure; halogenation; nonhuman; pharmacological parameters; Review; sponge (Porifera); Suberea; animal; chemistry; classification; drug development; human; metabolism; sponge (Porifera), Animals; Biological Products; Drug Discovery; Humans; Porifera
