Τίτλος:
Diabetic skin and UV light: Protection by antioxidants
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Non-invasive biophysical methods were used to study the effect of antioxidant gels, which were prepared from Pinus halepensis bark extracts, vitamin C and water, on the skin of diabetic hairless mice irradiated with UV radiation of 1 and 2 minimal erythemal doses (MEDs). The calculated transepidermal water loss (TEWL) for diabetic mice was found to be fivefold higher on day 11 after irradiation, and in all cases, the TEWL values converged to their initial values on day 21. Both pinus and vitamin C gels inhibited the dehydration of the skin, while water gels did not show similar protection. At low dose of UV-irradiation (1 MED), vitamin C gels showed the best hydration, while by doubling the UV dose, pinus gels induced significant skin-protective effects. Upon irradiation, the mice treatment with pinus gel showed diminished inflammation in comparison with the other gels. Pinus also inhibited the hyperkeratosis of skin. As expected, 2 MEDs caused greater skin damage, such as inflammation, dryness, oxidative stress and rides (aging) compared to the damage induced by 1 MED. © 2018 Elsevier B.V.
Συγγραφείς:
Dimaki, A.
Kyriazi, M.
Leonis, G.
Sfiniadakis, I.
Papaioannou, G.T.
Ioannou, E.
Roussis, V.
Rallis, M.
Περιοδικό:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Λέξεις-κλειδιά:
antioxidant; ascorbic acid; Pinus halepensis bark extract; plant extract; pyrethrin; skin protective agent; unclassified drug; antioxidant; ascorbic acid; plant extract; vitamin; water, animal cell; animal experiment; animal model; animal tissue; antioxidant activity; Article; bark; comparative study; controlled study; dehydration; erythema; gel; glucose blood level; hairless mouse; hyperkeratosis; male; mouse; nonhuman; oxidative stress; photoaging; pine; Pinus halepensis; priority journal; skin defect; skin protection; skin water loss; skinfold thickness; streptozotocin-induced diabetes mellitus; ultraviolet irradiation; animal; bark; cutaneous parameters; drug effect; experimental diabetes mellitus; gel; pathology; skin; ultraviolet radiation, Animals; Antioxidants; Ascorbic Acid; Diabetes Mellitus, Experimental; Gels; Male; Mice, Hairless; Oxidative Stress; Pinus; Plant Bark; Plant Extracts; Skin; Skin Aging; Ultraviolet Rays; Vitamins; Water
DOI:
10.1016/j.ejps.2018.10.010
