Τίτλος:
Cranberry: A promising natural source of potential nutraceuticals with anticancer activity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Studies have shown that cranberry and its components may exert anticancer properties. The present study aims to critically summarise the existing experimental studies evaluating the potential effects of cranberry on cancer prevention and treatment. PubMed database was searched to identify relevant studies. Current in vitro studies have indicated that cranberry and/or its components may act as chemopreventive agents, diminishing the risk for cancer by inhibiting cells oxidation and inflammatory-related processes, while they may also exert chemotherapeutic effects by inhibiting cell proliferation and angiogenesis, inducing cell apoptosis and attenuating the ability of tumour cells to invade and metastasis. Limited in vivo studies have further documented potential anticancer activity. Cranberry could be considered as a conglomeration of potential effective anticancer drug-like compounds. © 2019 Bentham Science Publishers.
Συγγραφείς:
Mantzorou, M.
Zarros, A.
Vasios, G.
Theocharis, S.
Pavlidou, E.
Giaginis, C.
Περιοδικό:
Anti-Cancer Agents in Medicinal Chemistry
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
anthocyanin; beclin 1; caffeic acid; catechin; cranberry extract; cyanidin; cyclooxygenase 2; ellagic acid; epidermal growth factor receptor; ferulic acid; flavonoid; flavonol; myricetin; nutraceutical; peonidin; phytochemical; polyphenol; proanthocyanidin; prostaglandin; protein Bax; protein bcl 2; quercetin; reactive oxygen metabolite; triterpenoid; unclassified drug; ursolic acid; antineoplastic agent; antioxidant; plant extract, angiogenesis; antiangiogenic activity; antiinflammatory activity; antineoplastic activity; antioxidant activity; antiproliferative activity; apoptosis; bladder cancer; breast cancer; cancer growth; cancer prevention; cancer risk; cancer therapy; cell proliferation; chemical structure; colon adenocarcinoma; colon cancer; cranberry; esophagus cancer; gene expression; Helicobacter infection; human; intestine cancer; liver cancer; liver cell carcinoma; metastasis; mouth cancer; nonhuman; ovary cancer; oxidative stress; prostate cancer; Review; stomach cancer; chemistry; cranberry; dietary supplement; drug effect; neoplasm; pathology, Antineoplastic Agents, Phytogenic; Antioxidants; Cell Proliferation; Dietary Supplements; Humans; Neoplasms; Plant Extracts; Vaccinium macrocarpon
DOI:
10.2174/1871520619666190704163301
