Τίτλος:
Association study of the CTH 1364 G>T polymorphism with coronary artery disease in the Greek population
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Cystathionine γ-lyase enzyme, which is encoded by the CTH gene, is responsible for hydrogen sulfide (H2S) production in the endothelium. The CTH 1364 G>T polymorphism may alter the CTH expression and H2S bioavailability, thus leading to atherosclerosis and coronary artery disease (CAD). We examined the potential association of the CTH 1364 G>T polymorphism with CAD. The CTH 1364 G>T polymorphism was determined in 178 coronary artery bypass grafting (CABG) patients and 156 non-atherosclerotic controls of Greek Caucasian origin using the PCR-RFLP method. No significant difference in the frequency of the CTH 1364 G>T genotypes (p = 0.281) and alleles (p = 0.265) was found between the CABG patients and controls. After conducting stratification according to sex, analysis showed a numerical difference in the CTH 1364 TT genotype frequency in female participants that did not reach statistical significance (16.3% and 8.5% in the CABG and controls, respectively, p = 0.26). The frequency of the CTH 1364 TT genotype between the male CABG patients and controls did not differ (p = 0.507). The CTH 1364 G>T polymorphism was not associated with CAD in the studied population. However, interestingly, a higher - if not significantly so - CTH 1364 TT genotype frequency was present in female CABG patients compared with female controls. Larger studies are necessary to conclude on the potential overall or gender-driven association between CTH 1364 G>T gene polymorphism and CAD. © 2019 Walter de Gruyter GmbH, Berlin/Boston.
Συγγραφείς:
Giannakopoulou, E.
Konstantinou, F.
Ragia, G.
Gerontitis, Z.
Tavridou, A.
Papapetropoulos, A.
Mikroulis, D.
Manolopoulos, V.G.
Περιοδικό:
Drug Metabolism and Personalized Therapy
Εκδότης:
De Gruyter Mouton
Λέξεις-κλειδιά:
glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; cystathionine gamma lyase, adult; aged; Article; case control study; cholesterol blood level; controlled study; coronary artery bypass graft; coronary artery disease; DNA isolation; DNA polymorphism; female; gene frequency; genetic association study; genetic variation; genotype; Greek (people); human; major clinical study; male; polymerase chain reaction; restriction fragment length polymorphism; coronary artery disease; genetics; Greece; middle aged; single nucleotide polymorphism, Aged; Case-Control Studies; Coronary Artery Disease; Cystathionine gamma-Lyase; Female; Genotype; Greece; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide
DOI:
10.1515/dmpt-2018-0033
