Τίτλος:
Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Paraoxonase-1 (PON-1) is a calcium-dependent enzyme that is synthesized in the liver and then secreted in blood where it is bound to High Density Lipoprotein (HDL). PON-1 is a hydrolase with a wide range of substrates, including lipid peroxides. It is considered responsible for many of the antia-therogenic properties of HDL. PON-1 prevents Low Density Lipoprotein (LDL) oxidation, a process that is considered to contribute to the initiation and development of atherosclerosis. PON-1 activity and levels are influenced by gene polymorphisms; of the 2 common variants, one is in position 192 (Q192R) and one in position 55 (M55L). Also, many drugs affect PON-1 activity. The role of PON-1 in carotid atherosclerosis is inconsistent. Some studies show an association of PON-1 polymorphisms with carotid plaque formation, whereas others do not. The aim of this review is to summarize the characteristics of PON-1, its interactions with drugs and its role in atherosclerosis and especially its relationship with carotid artery disease. © 2019 Bentham Science Publishers.
Συγγραφείς:
Lioudaki, S.
Verikokos, C.
Kouraklis, G.
Ioannou, C.
Chatziioannou, E.
Perrea, D.
Klonaris, C.
Περιοδικό:
Current Vascular Pharmacology
Εκδότης:
Bentham Science Publishers B.V.
Λέξεις-κλειδιά:
alloenzyme; amlodipine; antioxidant; apolipoprotein A1; aryldialkylphosphatase 1; atorvastatin; clusterin; fatty acid; fibrinogen; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; low density lipoprotein cholesterol; olmesartan; probucol; reactive nitrogen species; reactive oxygen metabolite; simvastatin; triacylglycerol; aryldialkylphosphatase; PON1 protein, human, amino acid sequence; atherosclerosis; atherosclerotic plaque; carotid artery disease; disease course; disease exacerbation; disease severity; enzyme activity; foam cell; genetic polymorphism; genetic variability; genotype; heart protection; human; hypercholesterolemia; hyperlipidemia; hypertension; ischemic heart disease; lipid oxidation; macrophage; meta analysis (topic); nonhuman; oxidative stress; protein lipid interaction; Review; risk factor; artery; atherosclerosis; atherosclerotic plaque; carotid artery disease; enzymology; genetics; metabolism; pathology; prognosis; risk assessment; signal transduction, Arteries; Aryldialkylphosphatase; Atherosclerosis; Carotid Artery Diseases; Disease Progression; Humans; Plaque, Atherosclerotic; Polymorphism, Genetic; Prognosis; Risk Assessment; Risk Factors; Signal Transduction
DOI:
10.2174/1570161115666171129212359
