Τίτλος:
Associations between adiponectin gene variability, pro-inflammatory and angiogenetic markers: Implications for microvascular disease development in type 2 diabetes mellitus?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Adiponectin gene (ADIPOQ) variability may affect the risk for type 2 diabetes mellitus (T2DM) but it remains unclear whether it is involved in microvascular complications. Objective: To explore the impact of ADIPOQ variability on markers of inflammation and angiogenesis in T2DM. Methods: Overall, 220 consecutive T2DM patients from our outpatient diabetic clinic were genotyped for G276T (rs1501299) and T45G (rs2241766) single nucleotide polymorphisms of ADIPOQ gene. Serum levels of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), vascular endothelial growth factor (VEGF) were measured by enzyme-linked immunosorbent assay and high sensitivity C-reactive protein (hsCRP) by immunonephelometry. Results: Homozygosity for the G allele on rs2241766 was associated with significantly lower serum VEGF and ICAM-1 levels compared with other genotype groups, but had no effect on IL-6. Genetic variability on rs1501299 was not associated with either VEGF or ICAM-1 levels, but T homozygotes for rs1501299 had significantly lower IL-6 concentrations compared with G carriers. Furthermore, the presence of the G allele on rs2241766 was associated with significantly lower HbA1c, whereas no associations were observed for both body mass index and hsCRP with either rs2241766 or rs1501299. Conclusion: Genetic variability on adiponectin gene was associated with serum levels of inflammatory and angiogenetic markers. Further research is required to elucidate the role of adiponectin in the development and/or progression of microvascular disease in T2DM patients. © 2019 Bentham Science Publishers.
Συγγραφείς:
Kollia, C.
Antonopoulos, A.S.
Siasos, G.
Konsola, T.
Oikonomou, E.
Gouliopoulos, N.
Tsigkou, V.
Papapanagiotou, A.
Kassi, E.
Tentolouris, N.
Katsiki, N.
Vavuranakis, M.
Papavassiliou, A.G.
Tousoulis, D.
Περιοδικό:
Current Vascular Pharmacology
Εκδότης:
Bentham Science Publishers B.V.
Λέξεις-κλειδιά:
adiponectin; angiogenic protein; C reactive protein; hemoglobin A1c; intercellular adhesion molecule 1; interleukin 6; vasculotropin; adiponectin; ADIPOQ protein, human; autacoid; biological marker; C reactive protein; ICAM1 protein, human; IL6 protein, human; intercellular adhesion molecule 1; interleukin 6; vasculotropin A; VEGFA protein, human, aged; Article; body mass; cholesterol blood level; coronary artery disease; disease course; disease duration; dyslipidemia; enzyme linked immunosorbent assay; family history; female; gene frequency; genetic association; genetic variability; genotype; human; hypertension; inflammation; major clinical study; male; microangiopathy; nephelometry; non insulin dependent diabetes mellitus; polymerase chain reaction; risk factor; single nucleotide polymorphism; angiogenesis; blood; cross-sectional study; diabetic angiopathy; genetics; non insulin dependent diabetes mellitus; pathophysiology; risk assessment; single nucleotide polymorphism, Adiponectin; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Neovascularization, Physiologic; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Vascular Endothelial Growth Factor A
DOI:
10.2174/1570161116666180108113825
