Τίτλος:
Critical role of IL-8 targeting in gliomas
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Glioma is a heterogeneous, highly complicated central nervous system (CNS) tumor with uncertain mechanism of initiation and progression, resulting in an unfavorable outcome. An extended network of cytokines is recognized as a major regulator of glioma pathogenesis, either promoting or inhibiting glioma progression based on their type and specificity. Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas. Objective: The aim of the present review is to address the role of IL-8 in glioma pathogenesis focusing on the implicated molecular pathways as well as on its potential targeting for glioma therapy. Methods and Results: PubMed-Medline, SCOPUS, and Google Scholar databases were searched for pre-clinical and clinical studies related to IL-8 implication in gliomagenesis and IL-8 targeting strategies for gliomas. Literature data indicate that IL-8 participates in glioma angiogenesis and cell migration and it can serve as a potential biomarker, for early diagnosis, follow-up and response to therapy. Conclusion: Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms. © 2018 Bentham Science Publishers.
Συγγραφείς:
Kosmopoulos, M.
Christofides, A.
Drekolias, D.
Zavras, P.D.
Gargalionis, A.N.
Piperi, C.
Περιοδικό:
Current Medicinal Chemistry
Εκδότης:
Bentham Science Publishers B.V.
Λέξεις-κλειδιά:
biological marker; cediranib; dehydroxymethylepoxyquinomicin; interleukin 6; interleukin 8; transforming growth factor beta; tumor necrosis factor; antineoplastic agent; IL8 protein, human; interleukin 8; tumor marker, angiogenesis; astrocyte cell line; cell migration; chemoradiotherapy; data base; early diagnosis; follow up; glioblastoma; glioma; glioma cell; human; pathogenesis; Review; animal; antagonists and inhibitors; carcinogenesis; cell motion; chemically induced; down regulation; drug effect; genetics; glioma; metabolism; neovascularization (pathology), Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinogenesis; Cell Movement; Down-Regulation; Glioma; Humans; Interleukin-8; Neovascularization, Pathologic
DOI:
10.2174/0929867325666171129125712
