Τίτλος:
Clozapine associated with autoimmune reaction, fever and low level cardiotoxicity - a case report
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Clozapine is a second-generation antipsychotic drug used in treatment-resistant schizophrenia. Fever induced by clozapine is a rather frequent side-effect which usually occurs in the first 4 weeks of treatment. Despite its effectiveness, there are potentially life-Threatening adverse effects, such as cardiotoxicity. Case Report: We present the case of a 31-year-old caucasian male with refractory schizophrenia who developed benign fever, increase of C-reactive protein and high troponin levels, without presenting any other signs to myocarditis, on the 13th day under clozapine treatment, which declined progressively upon discontinuation of the drug. Discussion: This case hints at the presence of initially subclinical cardiotoxicity as an underlying factor in patients developing fever. Conclusion: Taking advantage of more sensitive methods for measuring troponin, clinicians would be promptly aware of this possible side-effect. This would allow for significant reduction of the risk of cardiac dysfunction, further attained by carefully monitoring the patient.
Συγγραφείς:
Gerasimou, C.
Vitali, G.P.
Vavougios, G.D.
Papageorgiou, C.
Douzenis, A.
Kokoris, S.I.
Liappas, I.
Rizos, E.
Περιοδικό:
In vivo (Athens, Greece)
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
C reactive protein; clozapine; creatine kinase MB; lorazepam; paracetamol; procalcitonin; troponin; clozapine; neuroleptic agent, adult; agitation; Article; auditory hallucination; autoimmune disease; cardiotoxicity; case report; delusional disorder; drug dose increase; drug dose titration; drug withdrawal; electrocardiography; fever; gene expression; human; leukocyte count; leukocytosis; male; Mini Mental State Examination; myocarditis; neutrophil; rigor; schizophrenia; sinus tachycardia; sweating; tachycardia; thorax radiography; urinalysis; autoimmunity; cardiotoxicity; chemically induced; drug effects; fever, Adult; Antipsychotic Agents; Autoimmunity; Cardiotoxicity; Clozapine; Electrocardiography; Fever; Humans; Male; Schizophrenia
DOI:
10.21873/invivo.11037
