Τίτλος:
Simple physicochemical properties related with lipophilicity, polarity, molecular size and ionization status exert significant impact on the transfer of drugs and chemicals into human breast milk
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: The transfer of xenobiotic compounds into human breast milk has raised serious concerns in the last few years. The present study is aimed to assess whether simple physicochemical properties exert significant impact on human breast milk transfer of drugs and chemicals. Methods: A large data set of 375 xenobiotic compounds with available experimental milk to plasma (M/P) ratios was systematically compiled from the literature and explored with their physicochemical properties being further analyzed with respect to their extent to transfer into breast milk. Results: Xenobiotic compounds with increased breast milk transfer (M/P ≥ 1) were characterized by enhanced lipophilicity and decreased molecular size (p < 0.05). Enhanced polarity and hydrogen bonding capacity were more frequently observed in xenobiotic compounds with reduced breast milk transfer (p < 0.0001). Xenobiotic compounds presenting increased positive charge at pH 7.4 were characterized by enhanced breast milk transfer (p < 0.001). Xenobiotic compounds presenting increased negative charge at pH 7.4 were characterized by decreased breast milk transfer (p < 0.001). Conclusions: The present study supports evidence that simple physicochemical properties related with lipophilicity, polarity, molecular size and ionization status exert significant impact on drugs and chemicals transport into human breast milk. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Vasios, G.
Kosmidi, A.
Kalantzi, O.-I.
Tsantili-Kakoulidou, A.
Kavantzas, N.
Theocharis, S.
Giaginis, C.
Περιοδικό:
Expert Opinion on Drug Metabolism and Toxicology
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
insecticide; xenobiotic agent, Article; breast milk; breast milk transfer; drug absorption; human; hydrogen bond; ionization; lipophilicity; maternal plasma; milk to plasma ratio; molecular size; nutrient; pH; physical chemistry; polarity; pollutant
DOI:
10.1080/17425255.2016.1230197
