Τίτλος:
Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Evaluate the impact of reduced gastric acid secretion after administration of two acid-reducing agents on the physicochemical characteristics of contents of upper gastrointestinal lumen of fasted adults. Materials and Methods: Eight healthy male adults, fasted from food for 12 h, participated in a three-phase crossover study. Phase 1: No drug treatment prior to aspirations. Phase 2: Oral administration of 40 mg pantoprazole at ~9 am the last 3 days prior to aspirations and at ~7 am on aspiration day. Phase 3: Oral administration of 20 mg famotidine at ~7 pm prior to aspirations and at ~7 am on aspiration day. Samples from the contents of upper gastrointestinal lumen were aspirated for 50 min, after administration of 240 ml table water at ~9 am. Results: Reduction of gastric acid secretion was accompanied by reduced buffer capacity, chloride ion concentration, osmolality and surface tension in stomach and by increased pH (up to ~0.7 units) in upper small intestine during the first 50 min post-water administration. The mechanism of reduction of acid secretion seems to be important for the buffer capacity in stomach and for the surface tension in upper gastrointestinal lumen. Conclusions: Apart from gastric pH, reduced acid secretion affects physicochemical characteristics of contents of upper gastrointestinal lumen which may be important for the performance of certain drugs/products in the fasted state. © 2016, Springer Science+Business Media New York.
Συγγραφείς:
Litou, C.
Vertzoni, M.
Goumas, C.
Vasdekis, V.
Xu, W.
Kesisoglou, F.
Reppas, C.
Περιοδικό:
Pharmaceutical Research
Εκδότης:
Springer New York LLC
Λέξεις-κλειδιά:
buffer; chloride ion; cholesterol; famotidine; glycochenodeoxycholic acid; glycocholic acid; pantoprazole; phosphatidylcholine; protein; water; 2 [[(2 pyridyl)methyl]sulfinyl]benzimidazole derivative; bile acid; chloride; famotidine; histamine H2 receptor antagonist; pantoprazole; proton pump inhibitor, adult; Article; controlled study; crossover procedure; diet restriction; gastric suction; human; human experiment; limit of quantitation; male; morning dosage; normal human; osmolality; physical chemistry; priority journal; protein content; small intestine; stomach acid secretion; stomach content; stomach juice; stomach pH; surface tension; upper gastrointestinal tract; viscosity; achlorhydria; chemically induced; chemistry; clinical trial; comparative study; diet restriction; drinking; drug administration; drug effects; drug interaction; Greece; metabolism; oral drug administration; osmolarity; pH; secretion (process); stomach acid; stomach juice; stomach mucosa; suction; time factor; young adult, 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Administration, Oral; Adult; Bile Acids and Salts; Buffers; Chlorides; Cross-Over Studies; Drinking; Drug Administration Schedule; Drug Interactions; Famotidine; Fasting; Gastric Acid; Gastric Mucosa; Gastrointestinal Contents; Greece; Healthy Volunteers; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Osmolar Concentration; Proton Pump Inhibitors; Suction; Surface Tension; Time Factors; Young Adult
DOI:
10.1007/s11095-016-1882-8
