Περίληψη:
Seven new (1–3, 5 and 8–10) and three previously reported (4, 6 and 7) 4α-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5–8 exhibited cytotoxic activity against K562 human chronic myelogenous leukemia cells with IC50values below 10 μM, while at the same time displaying low toxicity against healthy PBMCs. © 2016 Elsevier Inc.
Συγγραφείς:
Zovko Končić, M.
Ioannou, E.
Sawadogo, W.R.
Abdel-Razik, A.F.
Vagias, C.
Diederich, M.
Roussis, V.
Λέξεις-κλειδιά:
4alpha methylated steroid; 4alpha,23,24 trimethyl 5alpha cholest 22 en 3beta,8beta,11beta triol; 4alpha,24 dimethyl 5alpha cholest 22 en 3beta,8beta triol; 4alpha,24 dimethyl 5alpha cholest 22 en 3beta,8beta,11beta triol; 4alpha,24 dimethyl 5alpha cholest 22,24(28) dien 3beta,8beta,18 triol; 4alpha,24 dimethyl 5alpha cholest 24(28) en 3beta,8beta,18 triol; 4alpha,24xi dimethyl 5alpha cholest 22 en 3beta,8beta,11beta triol; acetoxy 4alpha,24 dimethyl 5alpha cholest 24(28) 3beta,8beta,11beta; antineoplastic agent; nebrosteroid A; nebrosteroid D; nebrosteroid M; steroid; unclassified drug; steroid, antineoplastic activity; Article; cancer cell culture; carbon nuclear magnetic resonance; chronic myeloid leukemia; controlled study; coral; cytotoxicity; drug isolation; human; human cell; Litophyton mollis; lung cancer; mass spectrometry; peripheral blood mononuclear cell; proton nuclear magnetic resonance; animal; Anthozoa; cell survival; chemical structure; chemistry; cytology; drug effects; K-562 cell line; nuclear magnetic resonance spectroscopy, Animals; Anthozoa; Cell Survival; Humans; K562 Cells; Magnetic Resonance Spectroscopy; Molecular Structure; Steroids
