Τίτλος:
Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: An effect reversed by thyroxine pretreatment
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutamine administration (10 μg/kg/min) during the reperfusion period resulted in deterioration of functional recovery, which was abolished by propranolol administration. Long-term thyroxine pretreatment (12.5 μg 100 g-1 body weight, b.i.d., s.c., for 2 weeks) reversed the detrimental effect of dobutamine and increased postischaemic recovery of function. We conclude that the combination of thyroxine pretreatment and dobutamine administration could potentially be a new therapeutic strategy to improve postischaemic dysfunction particularly in clinical settings such as cardiopulmonary bypass and/or myocardial infarction. © 2003 Elsevier Science B.V. All rights reserved.
Συγγραφείς:
Pantos, C.
Mourouzis, I.
Tzeis, S.
Moraitis, P.
Malliopoulou, V.
Cokkinos, D.D.
Carageorgiou, H.
Varonos, D.
Cokkinos, D.
Περιοδικό:
European Journal of Pharmacology
Λέξεις-κλειδιά:
dobutamine; propranolol; thyroxine, animal tissue; article; controlled study; convalescence; disease exacerbation; drug effect; heart function; heart muscle ischemia; heart muscle reperfusion; long term care; nonhuman; priority journal; rat
DOI:
10.1016/S0014-2999(02)02927-8
