Τίτλος:
Antifungal activity of secondary metabolites of Centaurea raphanina ssp. mixta, growing wild in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The present study was carried out on the aerial parts of C. raphanina Sm. ssp. mixta (DC.) Runemark (Asteraceae), which is a commonly edible plant in Greece, on maturation stage. Although the isolation procedure is the appropriate one for the isolation of sesquiterpene lactones, the analysis revealed the presence of only one sesquiterpene lactone, namely cnicin, in small amounts. The main compounds were found to belong to polyphenols. The in vitro antifungal activity of the isolated compounds was tested, using the microdilution method. Only cnicin has been proved to be active against all fungi tested with a fungicidal potential higher than miconazole.
Συγγραφείς:
Panagouleas, C.
Skaltsa, H.
Lazari, D.
Skaltsounis, A.-L.
Sokovic, M.
Περιοδικό:
PHARMACEUTICAL BIOLOGY
Εκδότης:
Swets en Zeitlinger B.V.
Λέξεις-κλειδιά:
Centaurea raphanina mixta extract; cnicin; miconazole; polyphenol; sesquiterpene lactone derivative; unclassified drug, antifungal activity; article; Asteraceae; bioassay; Centauera raphanina mixta; drug structure; Greece; in vitro study; metabolite; minimum inhibitory concentration; plant; Streptomyces, Asteraceae; Centaurea; Centaurea raphanina; Centaurea raphanina; Fungi; Streptomyces
DOI:
10.1076/phbi.41.4.266.15664
