Τίτλος:
Effects of the flavonoid pilloin isolated from Marrubium cylleneum on mitogen-induced lymphocyte transformation
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Flavonoids are known to exhibit a wide range of biological functions. In the present study, the possible immunomodulatory and cytotoxic effects of pilloin, a flavone extracted from the Greek endemic herb Marrubium cylleneum were investigated by using the in vitro lymphocyte transformation and the cytotoxicity assays, respectively. Apigenin was used as the control flavonoid. Pilloin exerted a cytotoxic action targeted at the transformed lymphoblasts. On the other hand, the glycosylated flavonoid chrysoeriol-7-O-β-D-(3″-E-p-coumaroyl)-glucopyranoside was inactive, providing further evidence that glycosylation may eliminate the effects of aglycones.
Συγγραφείς:
Michelis, F.
Tiligada, E.
Skaltsa, H.
Lazari, D.
Skaltsounis, A.-L.
Delitheos, A.
Περιοδικό:
PHARMACEUTICAL BIOLOGY
Λέξεις-κλειδιά:
chrysoeriol 7 o beta dextro (3'' e 4 coumaroyl)glucopyranoside; flavanoid; pilloin; unclassified drug, article; bioassay; controlled study; cytotoxicity; drug effect; drug isolation; glycosylation; immunomodulation; in vitro study; lymphoblast; lymphocyte transformation; nonhuman, Lamiaceae; Marrubium
DOI:
10.1076/phbi.40.4.245.8472
