Τίτλος:
The influence of hydrophobic blocks of PEO-containing copolymers on glyceryl monooleate lyotropic liquid crystalline nanoparticles for drug delivery
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The investigation of properties of amphiphilic block copolymers as stabilizers for non-lamellar lyotropic liquid crystalline nanoparticles represents a fundamental issue for the formation, stability and upgraded functionality of these nanosystems. The aim of this work is to use am-phiphilic block copolymers, not studied before, as stabilizers of glyceryl monooleate 1-(cis-9-octa-decenoyl)-rac-glycerol (GMO) colloidal dispersions. Nanosystems were prepared with the use of poly(ethylene oxide)-b-poly(lactic acid) (PEO-b-PLA) and poly(ethylene oxide)-b-poly(5-methyl-5-ethyloxycarbonyl-1,3-dioxan-2-one) (PEO-b-PMEC) block copolymers. Different GMO:polymer molar ratios lead to formulation of nanoparticles with different size and internal organization, de-pending on the type of hydrophobic block. Resveratrol was loaded into the nanosystems as a model hydrophobic drug. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), fast Fourier transform (FFT) analysis and X-ray diffraction (XRD). The studies allowed the description of the lyotropic liquid crystalline nanoparticles and evaluation of impact of copolymer composition on these nanosystems. The structures formed in GMO:block copolymer colloidal dispersions were compared with those discussed previously. The investigations broaden the toolbox of polymeric stabilizers for the development of this type of hybrid polymer/li-pid nanostructures. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Forys, A.
Chountoulesi, M.
Mendrek, B.
Konieczny, T.
Sentoukas, T.
Godzierz, M.
Kordyka, A.
Demetzos, C.
Pispas, S.
Trzebicka, B.
Λέξεις-κλειδιά:
Aliphatic compounds; Block copolymers; Colloids; Dynamic light scattering; Ethylene; Fast Fourier transforms; High resolution transmission electron microscopy; Hydrophobicity; Liquid crystals; Molar ratio; Nanoparticles; Nanosystems; Polyethylene oxides, Amphiphilic block copolymers; Colloidal dispersion; Copolymer compositions; Cryogenic transmission electron microscopy (cryo-TEM); Glyceryl monooleate; Lyotropic liquid crystalline; Morphological characteristic; Polymeric stabilizers, Drug delivery
DOI:
10.3390/polym13162607
