Τίτλος:
Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Global epidemiological studies show that chronic non-communicable diseases such as atherosclerosis and metabolic disorders represent the leading cause of premature mortality and morbidity. Cardiovascular disease such as ischemic heart disease is a major contributor to the global burden of disease and the socioeconomic health costs. Clinical and epidemiological data show an association of typical oxidative stress markers such as lipid peroxidation products, 3-nitrotyrosine or oxidized DNA/RNA bases with all major cardiovascular diseases. This supports the concept that the formation of reactive oxygen and nitrogen species by various sources (NADPH oxidases, xanthine oxidase and mitochondrial respiratory chain) represents a hallmark of the leading cardiovascular comorbidities such as hyperlipidemia, hypertension and diabetes. These reactive oxygen and nitrogen species can lead to oxidative damage but also adverse redox signaling at the level of kinases, calcium handling, inflammation, epigenetic control, circadian clock and proteasomal system. The in vivo footprints of these adverse processes (redox biomarkers) are discussed in the present review with focus on their clinical relevance, whereas the details of their mechanisms of formation and technical aspects of their detection are only briefly mentioned. The major categories of redox biomarkers are summarized and explained on the basis of suitable examples. Also the potential prognostic value of redox biomarkers is critically discussed to understand what kind of information they can provide but also what they cannot achieve. © 2021 The Author(s)
Συγγραφείς:
Daiber, A.
Hahad, O.
Andreadou, I.
Steven, S.
Daub, S.
Münzel, T.
Λέξεις-κλειδιά:
3 nitrotyrosine; 4 hydroxynonenal; 8 isoprostane; biological marker; C reactive protein; DNA; endothelial nitric oxide synthase; glutathione; glutathione disulfide; heme oxygenase 1; malonaldehyde; manganese superoxide dismutase; microRNA; microRNA 107; microRNA 1254; microRNA 1306; microRNA 146a 5p; microRNA 199a; microRNA 21; microRNA 22 3p; microRNA 24; microRNA 26b 5p; microRNA 320a; microRNA 660 5p; microRNA 92a; myeloperoxidase; reactive nitrogen species; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase; reduced nicotinamide adenine dinucleotide phosphate oxidase 2; RNA; superoxide dismutase; transcription factor Nrf2; unclassified drug; vasodilator stimulated phosphoprotein; xanthine dehydrogenase; xanthine oxidase; biological marker; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide phosphate oxidase, alkylation; Article; atrial fibrillation; cardiovascular disease; cardiovascular mortality; cardiovascular risk factor; chemoluminescence; comorbidity; coronary artery disease; disease association; disease burden; disease severity; electron spin resonance; enzyme activation; enzyme activity; fluorescence analysis; heart failure; human; lipid peroxidation; nitration; nonhuman; oxidative stress; pathogenesis; predictive value; prognosis; protein expression; protein phosphorylation; redox signaling; respiratory chain; ST segment elevation myocardial infarction; sulfoxidation; ultraviolet visible spectrophotometry; cardiovascular disease; metabolism; oxidation reduction reaction, Biomarkers; Cardiovascular Diseases; Humans; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species
DOI:
10.1016/j.redox.2021.101875
