Τίτλος:
A novel synthetic protocol for the synthesis of pulvinones, and naturally occurring Aspulvinone E, molecules of medicinal interest
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A novel two step methodology for readily accessible natural “pulvinone” derivatives in excellent yields has been developed starting from activated precursors, bearing a functionalized 1,3-dioxolane-2,4-diones (OCA’s), as dually protected-activated synthons of α-hydroxy acids. The present procedure is based on a tandem C-acylation-cyclization process under mild conditions with good yields. Additionally, pulvinones show an important medicinal profile with the tetronate heterocycle exhibiting favorable pharmacokinetic (PK) and ADME-Tox properties that can be considered unexploited so far due to synthetic limitations. © 2021 Taylor & Francis Group, LLC.
Συγγραφείς:
Prousis, K.C.
Katsamakas, S.
Markopoulos, J.
Igglessi-Markopoulou, O.
Περιοδικό:
Synthetic Communications
Εκδότης:
Taylor and Francis Ltd.
DOI:
10.1080/00397911.2021.2001662
