Τίτλος:
Fabrication and Characterization of Neurocompatible Ulvan-Based Layer-by-Layer Films
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Construction of extracellular matrix-mimetic nanofilms has considerable potential in biomedical and nanomedicinal fields. In this work, we fabricated neurocompatible layer-by-layer (LbL) films based on ulvan (ULV), a highly sulfated polysaccharide having compositional similarity to glycosaminoglycans that play important functional roles in the brain. ULV was durably assembled as a film with chitosan, another marine-derived polysaccharide, and the film enabled the stable adhesion of primary hippocampal neurons with high viability, comparable to the conventional poly-d-lysine surface. Notably, the ULV-based LbL films accelerated neurite outgrowth and selectively suppressed the adhesion of astrocytes, highlighting its potential as an advanced platform for neural implants and devices. © 2020 American Chemical Society.
Συγγραφείς:
Moon, H.C.
Choi, H.
Kikionis, S.
Seo, J.
Youn, W.
Ioannou, E.
Han, S.Y.
Cho, H.
Roussis, V.
Choi, I.S.
Εκδότης:
American Chemical Society
Λέξεις-κλειδιά:
Adhesion; Amino acids; Neurons, Compositional similarities; Extracellular matrices; Fabrication and characterizations; Glycosaminoglycans; Layer-by-layer films; Neurite outgrowth; Primary hippocampal neurons; Sulfated polysaccharides, Fabrication
DOI:
10.1021/acs.langmuir.0c02173
