Τίτλος:
Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
This study aims at the further expansion of knowledge on the antimicrobial activities of the tetramic acid moiety and the effect of metal complexation. Complexes of the N-acetyl-3-acetyl-5-benzylidenetetramic acid with Mn, Co, Ni, Cu, Zn and Cd were synthesized and screened against 5 key ESKAPE pathogens (Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) and 2 fungi (Cryptococcus neoformans and Candida albicans). The cadmium complex was found to effectively inhibit the fungus Cryptococcus neoformans with minimum inhibitory concentration (MIC) of 8 μg/mL, with no human cell toxicity and hemolytic activity within the tested concentration range. The biologically active tetramic acid‑cadmium complex was structurally characterized by single-crystal X-ray analysis. Furthermore, the thermal stability of the ligand and the complexes was investigated along with NMR and EPR studies of the Cd(II) and Co(II) complexes respectively. © 2019 Elsevier Inc.
Συγγραφείς:
Matiadis, D.
Tsironis, D.
Stefanou, V.
Elliott, A.G.
Kordatos, K.
Zahariou, G.
Ioannidis, N.
McKee, V.
Panagiotopoulou, A.
Igglessi-Markopoulou, O.
Markopoulos, J.
Περιοδικό:
Journal of Inorganic Biochemistry
Εκδότης:
ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Λέξεις-κλειδιά:
acetic acid derivative; antifungal agent; cadmium; cobalt; copper; manganese; metal complex; nickel; tetramic acid derivative; zinc; antifungal agent; antiinfective agent; coordination compound, Acinetobacter baumannii; antifungal activity; Article; Candida albicans; carbon nuclear magnetic resonance; Cryptococcus neoformans; drug structure; drug synthesis; electron spin resonance; embryo; Escherichia coli; hemolysis; human; human cell; Klebsiella pneumoniae; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; nonhuman; proton nuclear magnetic resonance; Pseudomonas aeruginosa; thermostability; X ray analysis; bacterium; chemistry; Deuteromycetes; drug effect; erythrocyte; HEK293 cell line; microbial sensitivity test; synthesis; X ray crystallography, Anti-Bacterial Agents; Antifungal Agents; Bacteria; Cadmium; Coordination Complexes; Crystallography, X-Ray; Erythrocytes; HEK293 Cells; Hemolysis; Humans; Microbial Sensitivity Tests; Mitosporic Fungi
DOI:
10.1016/j.jinorgbio.2019.02.008
