Περίληψη:
We compared the effects of Heat-not-Burn cigarette (HNBC) to those of
tobacco cigarette (Tcig), on myocardial, coronary and arterial function
as well as on oxidative stress and platelet activation in 75 smokers. In
the acute study, 50 smokers were randomised into smoking a single Tcig
or a HNBC and after 60 min were crossed-over to the alternate smoking.
For chronic phase, 50 smokers were switched to HNBC and were compared
with an external group of 25 Tcig smokers before and after 1 month.
Exhaled carbon monoxide (CO), pulse wave velocity (PWV), malondialdehyde
(MDA) and thromboxane B2 (TxB2) were assessed in the acute and chronic
study. Global longitudinal strain (GLS), myocardial work index (GWI),
wasted myocardial work (GWW), coronary flow reserve (CFR), total
arterial compliance (TAC) and flow-mediated dilation (FMD) were assessed
in the chronic study. Acute HNBC smoking caused a smaller increase of
PWV than Tcig (change 1.1 vs 0.54 m/s, p<0.05) without change in CO and
biomarkers in contrast to Tcig. Compared to Tcig, switching to HNBC for
1-month improved CO, FMD, CFR, TAC, GLS, GWW, MDA, TxB2 (differences
10.42 ppm, 4.3%, 0.98, 1.8 mL/mmHg, 2.35%, 19.72 mmHg%, 0.38 nmol/L
and 45 pg/mL respectively, p<0.05). HNBCs exert a less detrimental
effect on vascular and cardiac function than tobacco cigarettes.Trial
registration Registered on https://clinicaltrials.gov/ (NCT03452124,
02/03/2018).
Συγγραφείς:
Ikonomidis, Ignatios
Vlastos, Dimitrios
Kostelli, Gavriela and
Kourea, Kallirhoe
Katogiannis, Konstantinos
Tsoumani, Maria and
Parissis, John
Andreadou, Ioanna
Alexopoulos, Dimitrios
