Τίτλος:
Aquagenic wrinkling of the palms after brief immersion to water test as
a screening tool for cystic fibrosis diagnosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Aquagenic wrinkling of the palms (AWP) is an excessive and
early palmar wrinkling occurring after Brief Immersion to Water (BIW),
and has been reported as a frequent finding among cystic fibrosis (CF)
patients.
Objectives To evaluate and assess the diagnostic performance of BIW test
as an initial screening tool for CF diagnosis.
Methods We measured AWP in CF patients, CF-heterozygotes (CF-het) and
normal controls. The AWP parameters of palmar wrinkling, oedema,
papules, pruritus and pain were assessed at 3, 7 and 11 min after a BIW
test was performed for all the participants. Statistical analyses
explored the progression of AWP in time for the three groups and
assessed the diagnostic performance of BIW test as a diagnostic
screening tool for CF.
Results A total of 250 individuals (100 CF patients, their 50 CF-het
parents, 100 healthy controls) were included in the analysis. The
average age in years (mean +/- SD) was 10.4 +/- 4.0 for CF, 35.9 +/- 6.1
for CF-het and 10.5 +/- 4.0 for controls. The rate of positives for AWP
at 3 min among CF patients, CF-het and controls was 68%, 8% and 0%,
respectively (P < 0.01). Kaplan-Meier analysis showed a clear trend
towards earlier appearance of all five parameters in the direction
controls < hetCF < CF (P values <0.01). The best diagnostic performance
in detecting between CF patients and non-CF was achieved by the presence
of papules and wrinkling at 7 min (sensitivity/specificity:
94.0%/98.3% and 100.0%/92.0%, respectively).
Conclusions A strong association between AWP and CF was detected. AWP
after BIW could be elicited easily and possibly can be used as an
initial screening tool to assess if an individual with symptoms and
signs that raise the likelihood of CF is a CF patient.
Συγγραφείς:
Alexopoulos, A.
Chouliaras, G.
Kakourou, T.
Dakoutrou, M.
and Nasi, L.
Petrocheilou, A.
Siahanidou, S. and
Kanaka-Gantenbein, C.
Chrousos, G.
Loukou, I.
Michos, A.
Περιοδικό:
Journal of the European Academy of Dermatology and Venereology
