Τίτλος:
BioFire (R) FilmArray (R) Pneumonia Panel for Severe Lower Respiratory
Tract Infections: Subgroup Analysis of a Randomized Clinical Trial
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: The epidemiology of severe lower respiratory tract
infections (LRTI) is constantly changing. We aimed to describe it using
the BioFire (R) FilmArray (R) Pneumonia plus (PNplus) Panel.
Methods: In a sub-study of the PROGRESS trial, sputum samples of 90
patients with sepsis and LRTI were retrospectively studied. The primary
endpoint was the comparative detection rate of pathogens between
conventional microbiology and PNplus Panel; secondary endpoints were
microbiology and the association with the inflammatory host response.
Results: Fifty-six patients with community-acquired pneumonia without
risk factors for multidrug-resistant (MDR) pathogens and another 34
patients with risk factors for MDR were studied; median pneumonia
severity index (PSI) was 113 (88-135). PNplus detection rate was 72.2%
compared to 10% by conventional microbiology (p < 0.001); Streptococcus
pneumoniae was the most common pathogen. PSI and procalcitonin were
greater among patients with bacterial pathogens than viral pathogens.
Median procalcitonin was 0.49 ng/ml and 0.18 ng/ml among patients with
>= 10(5) and < 10(5) copies/ml of detected bacteria, respectively (p =
0.004). Resistance reached 14.4%.
Conclusion: PNplus detects severe pneumonia pathogens at a greater rate
than conventional microbiology. High levels of inflammation accompany
bacterial detection.
Συγγραφείς:
Kyriazopoulou, Evdoxia
Karageorgos, Athanasios
Liaskou-Antoniou,
Lydia
Koufargyris, Panagiotis
Safarika, Asimina
Damoraki,
Georgia
Lekakis, Vasileios
Saridaki, Maria
Adamis, George
and Giamarellos-Bourboulis, Evangelos J.
Περιοδικό:
Infectious Diseases and Therapy
Εκδότης:
Springer-Verlag London Ltd
Λέξεις-κλειδιά:
FilmArray (R); Syndromic testing; Pneumonia; Procalcitonin; Lower
respiratory tract infection; S. pneumoniae
DOI:
10.1007/s40121-021-00459-x
