Τίτλος:
Past, Present, and Future of Gonadotropin Use in Controlled Ovarian
Stimulation During Assisted Reproductive Techniques
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A variety of protocols have evaluated the use of several forms of
gonadotropins in controlled ovarian stimulation (COS). We aim to review
the evolving trends on the use of gonadotropins human chorionic
gonadotropin (hCG), follicle-stimulating hormone (FSH) and luteinizing
hormone (LH) over time and their combinations in COS for patients who
undergo assisted reproductive techniques (ART) protocols. A meticulous
search of three electronic databases was performed for articles
published in the field up to September 2020. The administration of hCG
seems a promising alternative to conventional modalities for COS related
to the enhancement of LH activity. The use of gonadotropins was
associated with significantly elevated pregnancy rates that ranged from
20.8% to 46.2%. However, the currently available outcomes with regards
to oocytes retrieved, number of embryos are still conflicting. A
potential beneficial effect was observed by the majority of the studies
in terms of the number of embryos and implantation rates, which is,
however, highly affected by the type of protocol used
(gonadotropin-releasing hormone [GnRH] agonist or antagonist). Further
studies are warranted to elucidate the exact pathways of action of
gonadotropins in controlled ovarian stimulation to attain the optimal
effect.
Συγγραφείς:
Prodromidou, Anastasia
Anagnostou, Elli
Mavrogianni, Depy and
Liokari, Emmanouela
Dimitroulia, Evangelia
Drakakis, Petros and
Loutradis, Dimitrios
Λέξεις-κλειδιά:
assisted reproductive technology; controlled ovarian stimulation;
gonadotropins; human chorionic gonadotropin; human menopausal
gonadotropin
DOI:
10.7759/cureus.15663
