Τίτλος:
Interaction of schizophrenia and chronic cannabis use on reward
anticipation sensitivity
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Chronic cannabis use and schizophrenia are both thought to affect reward
processing. While behavioural and neural effects on reward processing
have been investigated in both conditions, their interaction has not
been studied, although chronic cannabis use is common among these
patients. In the present study eighty-nine participants divided into
four groups (control chronic cannabis users and non-users; schizophrenia
patient cannabis users and non-users) performed a two-choice decision
task, preceded by monetary cues (high/low reward/punishment or neutral),
while being scanned using functional magnetic resonance imaging. Reward
and punishment anticipation resulted in activation of regions of
interest including the thalamus, striatum, amygdala and insula. Chronic
cannabis use and schizophrenia had opposing effects on reward
anticipation sensitivity. More specifically control users and patient
non-users showed faster behavioural responses and increased activity in
anterior/posterior insula for high magnitude cues compared to control
non-users and patient users. The same interaction pattern was observed
in the activation of the right thalamus for reward versus punishment
cues. This study provided evidence for interaction of chronic cannabis
use and schizophrenia on reward processing and highlights the need for
future research addressing the significance of this interaction for the
pathophysiology of these conditions and its clinical consequences.
Συγγραφείς:
Fish, Simon
Christidi, Foteini
Karavasilis, Efstratios and
Velonakis, Georgios
Kelekis, Nikolaos
Klein, Christoph and
Stefanis, Nicholas C.
Smyrnis, Nikolaos
Περιοδικό:
npj Schizophrenia
Εκδότης:
Institute of Geographic Sciences and Natural Resources Research
DOI:
10.1038/s41537-021-00163-2
