Admission Neutrophil to Lymphocyte Ratio for Predicting Outcome in
Subarachnoid Hemorrhage

Chang, Jason J.; Dowlati, Ehsan; Triano, Matthew; Kalegha,; Enite; Krishnan, Rashi; Kasturiarachi, Brittany M. and; Gachechiladze, Leila; Pandhi, Abhi; Themistocleous, Marios and; Katsanos, Aristeidis H.; Felbaum, Daniel R.; Mai, Jeffrey C. and; Armonda, Rocco A.; Aulisi, Edward F.; Elijovich, Lucas; Arthur,; Adam S.; Tsivgoulis, Georgios; Goyal, Nitin

doi:10.1016/j.jstrokecerebrovasdis.2021.105936

Μονάδα:

Ερευνητικό υλικό ΕΚΠΑ

Τίτλος:

Admission Neutrophil to Lymphocyte Ratio for Predicting Outcome in
Subarachnoid Hemorrhage

Γλώσσες Τεκμηρίου:

Αγγλικά

Περίληψη:

Purpose: We sought to evaluate the relationship between admission
neutrophil-to-lymphocyte ratio (NLR) and functional outcome in
aneurysmal subarachnoid hemorrhage (aSAH) patients. Material and
methods: Consecutive patients with aSAH were treated at two tertiary
stroke centers during a five-year period. Functional outcome was defined
as discharge modified Rankin score dichotomized at scores 0-2 (good) vs.
3-6 (poor). Results: 474 aSAH patients were evaluated with a mean NLR
8.6 (SD 8.3). In multivariable logistic regression analysis, poor
functional outcome was independently associated with higher NLR, older
age, poorer clinical status on admission, prehospital statin use, and
vasospasm. Increasing NLR analyzed as a continuous variable was
independently associated with higher odds of poor functional outcome (OR
1.03, 95%CI 1.001.07, p=0.05) after adjustment for potential
confounders. When dichotomized using ROC curve analysis, a threshold NLR
value of greater than 6.48 was independently associated with higher odds
of poor functional outcome (OR 1.71, 95%CI 1.07-2.74, p=0.03) after
adjustment for potential confounders. Conclusions: Higher admission NLR
is an independent predictor for poor functional outcome at discharge in
aSAH patients. The evaluation of anti-inflammatory targets in the future
may allow for improved functional outcome after aSAH.

Έτος δημοσίευσης:

2021

Συγγραφείς:

Chang, Jason J.
Dowlati, Ehsan
Triano, Matthew
Kalegha,
Enite
Krishnan, Rashi
Kasturiarachi, Brittany M. and
Gachechiladze, Leila
Pandhi, Abhi
Themistocleous, Marios and
Katsanos, Aristeidis H.
Felbaum, Daniel R.
Mai, Jeffrey C. and
Armonda, Rocco A.
Aulisi, Edward F.
Elijovich, Lucas
Arthur,
Adam S.
Tsivgoulis, Georgios
Goyal, Nitin

Περιοδικό:

Journal of Stroke and Cerebrovascular Diseases

Εκδότης:

Elsevier

Τόμος:

Αριθμός / τεύχος:

Λέξεις-κλειδιά:

Subarachnoid hemorrhage; Aneurysmal subarachnoid hemorrhage;
Inflammation; Neutrophil-to-lymphocyte ratio; Outcome; Delayed cerebral
ischemia

Επίσημο URL (Εκδότης):

https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105936

DOI:

10.1016/j.jstrokecerebrovasdis.2021.105936