Περίληψη:
Introduction Severe asthma is a rare disease in children, for which
three biologicals, anti-immunoglobulin E, anti-interleukin-5 and
anti-IL4RA antibodies, are available in European countries. While global
guidelines exist on who should receive biologicals, knowledge is lacking
on how those guidelines are implemented in real life and which unmet
needs exist in the field. In this survey, we aimed to investigate the
status quo and identify open questions in biological therapy of
childhood asthma across Europe.
Methods Structured interviews regarding experience with biologicals,
regulations on access to the different treatment options, drug
selection, therapy success and discontinuation of therapy were
performed. Content analysis was used to analyse data.
Results We interviewed 37 experts from 25 European countries and Turkey
and found a considerable range in the number of children treated with
biologicals per centre. All participating countries provide public
access to at least one biological. Most countries allow different
medical disciplines to prescribe biologicals to children with asthma,
and only a few restrict therapy to specialised centres. We observed
significant variation in the time point at which treatment success is
assessed, in therapy duration and in the success rate of
discontinuation. Most participating centres intend to apply a
personalised medicine approach in the future to match patients a priori
to available biologicals.
Conclusion Substantial differences exist in the management of childhood
severe asthma across Europe, and the need for further studies on
biomarkers supporting selection of biologicals, on criteria to assess
therapy response and on how/when to end therapy in stable patients is
evident.
Συγγραφείς:
Santos-Valente, Elisangela
Buntrock-Dopke, Heike
Abou Taam, Rola
and Arasi, Stefania
Bakirtas, Arzu
Lozano Blasco, Jaime and
Bonnelykke, Klaus
Craiu, Mihai
Cutrera, Renato
Deschildre,
Antoine
Elnazir, Basil
Fleming, Louise
Frey, Urs
Gappa,
Monika
Nieto Garcia, Antonio
Hansen, Kirsten Skamstrup and
Hanssens, Laurence
Jahnz-Rozyk, Karina
Jesenak, Milos and
Kerzel, Sebastian
Kopp, V, Matthias
Koppelman, Gerard H. and
Krivec, Uros
MacLeod, Kenneth A.
Makela, Mika
Melen, Erik
and Mezei, Gyorgyi
Moeller, Alexander
Moreira, Andre and
Pohunek, Petr
Minic, Predrag
Rutjes, Niels W. P.
Sammut,
Patrick
Schwerk, Nicolaus
Szepfalusi, Zsolt
Turkalj, Mirjana
and Tzotcheva, Iren
Ulmeanu, Alexandru
Verhulst, Stijn and
Xepapadaki, Paraskevi
Niggel, Jakob
Vijverberg, Susanne and
Maitland-van der Zee, Anke H.
Potocnik, Uros
Reinartz, Susanne
M.
van Drunen, Cornelis M.
Kabesch, Michael
