Τίτλος:
Invasive Mucormycosis in Children With Malignancies: Report From the
Infection Working Group of the Hellenic Society of Pediatric
Hematology-Oncology
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Mucormycosis is an invasive, life-threatening fungal infection that
mainly affects immunocompromised hosts. We collected data of pediatric
mucormycosis cases from all 7 Greek Hematology-Oncology Departments for
the years 2008-2017. Six cases of invasive mucormycosis diagnosed during
treatment for malignancies were included in the study. In 4 children
(66%) mucormycosis occurred within the first 20 days after diagnosis of
the underlying disease. Two cases were classified as proven mucormycosis
and 4 as probable. The most frequently recorded species was Rhizopus
arrhizus (2 patients), followed by Mucor spp (1), and Lichtheimia spp
(1). All patients received liposomal amphotericin B. Combined antifungal
treatment was used in 5 cases. Surgical excision was performed in 4
cases (66%). Two patients died at 6 and 12 months after the diagnosis,
respectively, 1 (17%) because of mucormycosis. Our data suggest that
mucormycosis may occur early after the initiation of intensive
chemotherapy in children with malignancies.
Συγγραφείς:
Antoniadi, Kondilia
Iosifidis, Elias
Vasileiou, Eleni and
Tsipou, Charoula
Lialias, Ioannis
Papakonstantinou, Eugenia and
Kattamis, Antonios
Polychronopoulou, Sophia
Roilides, Emmanuel
and Tragiannidis, Athanasios
Περιοδικό:
Journal of Pediatric Hematology / Oncology
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
children; cancer; mucormycosis; zygomycosis; pediatric
DOI:
10.1097/MPH.0000000000001931
