Περίληψη:
Background: Tetracyclines and clindamycin plus rifampicin combination
therapy are both considered first-line therapy in current hidradenitis
suppurativa guidelines. However, evidence for their efficacy is drawn
from small studies, often without validated outcomes.
Objective: To assess the 12-week efficacy of oral tetracyclines and a
combination of clindamycin and rifampicin. Methods: A prospective,
international cohort study performed between October 2018 and August
2019.
Results: In total, 63.6% of the included 283 patients received oral
tetracyclines, and 36.4% were treated with clindamycin and rifampicin.
Both groups showed a significant decrease in International Hidradenitis
Suppurativa Severity Score System from baseline (both P < .001). The
Hidradenitis Suppurativa Clinical Response (HiSCR) was achieved in
40.1% and 48.2% of patients, respectively (P = .26). Patient
characteristics or disease severity were not associated with the
attainment of HiSCR or the minimal clinically important differences for
the Dermatology Life Quality Index and pain.
Limitations: Cohort study. Respectively, 23.9% and 19.4% of patients
had to be excluded from the HiSCR analysis for the tetracycline and
combination therapy group because of a low abscess and nodule count at
baseline.
Conclusion: This study shows significant efficacy of both tetracycline
treatment and clindamycin and rifampicin combination therapy after 12
weeks in patients with hidradenitis suppurativa. No significant
differences in efficacy were observed between the 2 treatments,
regardless of disease severity.
Συγγραφείς:
van Straalen, Kelsey R.
Tzellos, Thrasyvoulos
Guillem, Phillipe
and Benhadou, Farida
Cuenca-Barrales, Carlos
Daxhelet, Mathilde
and Daoud, Mathieu
Efthymiou, Ourania
Giamarellos-Bourboulis,
Evangelos J.
Jemec, Gregor B. E.
Katoulis, Alexandros C. and
Koenig, Anke
Lazaridou, Elizabeth
Marzano, V, Angelo and
Matusiak, Lucas
Molina-Leyva, Alejandro
Moltrasio, Chiara and
Pinter, Andreas
Potenza, Concetta
Romani, Jorge
Saunte,
Ditte M.
Skroza, Nevena
Stergianou, Dimitra
Szepietowski,
Jacek
Trigoni, Anastasia
Vilarrasa, Eva
van der Zee, Hessel
H.
