Τίτλος:
Stress hormones kinetics in ventricular fibrillation cardiac arrest and
resuscitation: Translational and therapeutic implications
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Knowing the kinetics of endogenous stress hormones during
cardiac arrest and cardiopulmonary resuscitation (CRP) will help to
optimize personalized physiology-guided treatment. The aim of this study
was to examine the dynamic changes in stress hormones in a swine model
of ventricular fibrillation (VF) cardiac arrest.
Methods: Ventricular fibrillation was induced in 10 healthy
Landrace/Large White piglets, which were subsequently left untreated for
8 min. All animals were resuscitated according to the 2015 European
Resuscitation Council guidelines. The concentration of adrenalin,
noradrenalin, and cortisol was measured at baseline and at the 4th and
8th minute of VF-cardiac arrest, as well as at 30-min, 60-min, 24 h and
48 h post-ROSC.
Results: By the end of the 4th min of VF, the animals of the ROSC group
exhibited significantly higher adrenaline levels compared to those of
the no-ROSC group (7264 pg/ml vs. 1648 pg/ml. p - 0.03). Noradrenaline
was higher in the ROSC group at the 4th min of VI (3021 pg/ml vs. 1626
pg/ml, p = 0.02). Cortisol levels in the ROSC group were significantly
lower by the end of the 8th min of VF[16.25 ng/ml vs. 92.82 ng/ml, p
0.031. With a cut-off point of 5970 pg/ml, adrenaline at the 4th min of
VF exhibited 100% sensitivity and 80% specificity for predicting ROSC.
Conclusion: Higher endogenous adrenaline and lower endogenous cortisol
levels were associated with ROSC. (C) 2021 Elsevier Inc. All rights
reserved.
Συγγραφείς:
Pantazopoulos, Ioannis
Boutsikos, Ioannis
Mavrovounis, Georgios
and Gkraikou, Themis
Faa, Gavino
Barouxis, Dimitrios and
Kesidou, Evangelia
Mavridis, Theodoros
Chalkias, Athanasios and
Xanthos, Theodoros
Περιοδικό:
The American Journal of Emergency Medicine
Εκδότης:
W B SAUNDERS CO-ELSEVIER INC
Λέξεις-κλειδιά:
Stress hormones; Resuscitation; ROSC; Ventricular fibrillation; Cardiac
arrest
DOI:
10.1016/j.ajem.2021.07.016
