Τίτλος:
Phytochemical Study and In Vitro Screening Focusing on the Anti-Aging
Features of Various Plants of the Greek Flora
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Skin health is heavily affected by ultraviolet irradiation from the sun.
In addition, senile skin is characterized by major changes in the
collagen, elastin and in the hyaluronan content. Natural products (NPs)
have been shown to delay cellular senescence or in vivo aging by
regulating age-related signaling pathways. Moreover, NPs are a
preferable source of photoprotective agents and have been proven to be
useful against the undesirable skin hyperpigmentation. Greek flora
harvests great plant diversity with approximately 6000 plant species, as
it has a wealth of NPs. Here, we report an extensive screening among
hundreds of plant species. More than 440 plant species and subspecies
were selected and evaluated. The extracts were screened for their
antioxidant and anti-melanogenic properties, while the most promising
were further subjected to various in vitro and cell-based assays related
to skin aging. In parallel, their chemical profile was analyzed with
High-Performance Thin-Layer Chromatography (HPTLC) and/or
Ultra-Performance Liquid Chromatography High-Resolution Mass
Spectrometry (UPLC-HRMS). A variety of extracts were identified that can
be of great value for the cosmetic industry, since they combine
antioxidant, photoprotective, anti-melanogenic and anti-aging
properties. In particular, the methanolic extracts of Sideritis scardica
and Rosa damascena could be worthy of further attention, since they
showed interesting chemical profiles and promising properties against
specific targets involved in skin aging.
Συγγραφείς:
Sklirou, Aimilia D.
Angelopoulou, Maria T.
Argyropoulou,
Aikaterini
Chaita, Eliza
Boka, Vasiliki Ioanna
Cheimonidi,
Christina
Niforou, Katerina
Mavrogonatou, Eleni
Pratsinis,
Harris
Kalpoutzakis, Eleftherios
Aligiannis, Nektarios and
Kletsas, Dimitris
Trougakos, Ioannis P.
Skaltsounis, Alexios
Leandros
Περιοδικό:
Free Radicals and Antioxidants
Λέξεις-κλειδιά:
skin health; aging; plant extracts; natural products; phytochemistry;
Sideritis scardica; Rosa damascena; senescence; photoprotection;
proteasome
DOI:
10.3390/antiox10081206
