Τίτλος:
Phenotypic/Genotypic Profile of OXA-10-Like-Harboring,
Carbapenem-Resistant Pseudomonas aeruginosa: Using Validated
Pharmacokinetic/Pharmacodynamic In Vivo Models To Further Evaluate
Enzyme Functionality and Clinical Implications
Περίληψη:
In vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime
human-simulated regimens (HSR) against modified carbapenem inactivation
method (mCIM)-positive Pseudomonas aeruginosa isolates harboring
different OXA-10-like sub-types were described. The murine thigh model
assessed ceftazidime (2 g every 8 h [q8h] HSR) and cefepime (2 g and 1
g q8h HSR). Phenotypes were similar despite possessing OXA-10-like
subtypes with differing spectra. Ceftazidime produced >= 1-log(10)
killing in all isolates. Cefepime activity was dose dependent and MIC
driven. This approach may be useful in assessing the implications of
beta-lactamase variants.
Συγγραφείς:
Gill, Christian M.
Brink, Adrian
Chu, Chun Yat
Coetzee,
Jennifer
Dimopoulos, George
Moodley, Clinton
Opperman,
Christoffel Johannes
Pournaras, Spyros
Tenover, Fred C. and
Tickler, Isabella A.
Tootla, Hafsah Deepa
Vourli, Sophia and
Nicolau, David P.
