Τίτλος:
Challenges and Scientific Prospects of the Newest Generation of
mRNA-Based Vaccines against SARS-CoV-2
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In the context of the current COVID-19 pandemic, traditional, complex
and lengthy methods of vaccine development and production would not have
been able to ensure proper management of this global public health
crisis. Hence, a number of technologies have been developed for
obtaining a vaccine quickly and ensuring a large scale production, such
as mRNA-based vaccine platforms. The use of mRNA is not a new concept in
vaccine development but has leveraged on previous knowledge and
technology. The great number of human resources and capital investements
for mRNA vaccine development, along with the experience gained from
previous studies on infectious diseases, allowed COVID-19 mRNA vaccines
to be developed, conditionally approved and commercialy available in
less than one year, thanks to decades of basic research. This review
critically presents and discusses the COVID-19 mRNA vaccine-induced
immunity, and it summarizes the most common anaphylactic and autoimmune
adverse effects that have been identified until now after massive
vaccination campaigns.
Συγγραφείς:
Calina, Daniela
Hernandez, Antonio F.
Hartung, Thomas and
Egorov, Alexey M.
Izotov, Boris Nikolaevich
Nikolouzakis,
Taxiarchis Konstantinos
Tsatsakis, Aristidis
Vlachoyiannopoulos,
Panayiotis G.
Docea, Anca Oana
Λέξεις-κλειδιά:
COVID-19 pandemic; public health; coronaviruses; mRNA vaccines; side
effects
DOI:
10.3390/life11090907
