Τίτλος:
Effects of a 12-Month Treatment with Glucagon-like Peptide-1 Receptor
Agonists, Sodium-Glucose Cotransporter-2 Inhibitors, and Their
Combination on Oxidant and Antioxidant Biomarkers in Patients with Type
2 Diabetes
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Imbalance between oxidative stress burden and antioxidant capacity is
implicated in the course of atherosclerosis among type 2 diabetic
patients. We addressed the effects of insulin, glucagon-like peptide-1
receptor agonists (GLP1-RA), sodium-glucose cotransporter-2 inhibitors
(SGLT-2i), and their combination on levels of oxidant and antioxidant
biomarkers. We recruited a total of 160 type 2 diabetics, who received
insulin (n = 40), liraglutide (n = 40), empagliflozin (n = 40), or their
combination (GLP-1RA+SGLT-2i) (n = 40). We measured at baseline, at 4
and at 12 months of treatment: (a) Thiobarbituric Acid Reactive
Substances (TBARS), (b) Malondialdehyde (MDA), (c) Reducing Power (RP),
(d) 2,2(SIC)-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radical
(ABTS) and (e) Total Antioxidant Capacity TAC). Dual treatment resulted
in significant improvement of TBARS, MDA, and ABTS at four months
compared with the other groups (p < 0.05 for all comparisons). At twelve
months, all participants improved TBARS, MDA, and ABTS (p < 0.05). At 12
months, GLP1-RA and GLP-1RA+SGLT2-i provided a greater reduction of
TBARS (-8.76% and -9.83%) compared with insulin or SGLT2i (-0.5% and
3.22%), (p < 0.05). GLP1-RA and GLP-1RA+SGLT-2i showed a greater
reduction of MDA (-30.15% and -31.44%) compared with insulin or SGLT2i
(4.72% and -3.74%), (p < 0.05). SGLT2i and GLP-1RA+SGLT2-i showed
increase of ABTS (12.87% and 14.13%) compared with insulin or GLP1-RA
(2.44% and -3.44%), (p < 0.05). Only combined treatment resulted in
increase of TAC compared with the other groups after 12 months of
treatment (p < 0.05).12-month treatment with GLP1-RA and SGLT2i resulted
in reduction of biomarkers responsible for oxidative modifications and
increase of antioxidant biomarker, respectively. The combination
treatment was superior and additive to each separate agent and also the
beneficial effects appeared earlier.
Συγγραφείς:
Lambadiari, Vaia
Thymis, John
Kouretas, Dimitris
Skaperda,
Zoi
Tekos, Fotios
Kousathana, Foteini
Kountouri, Aikaterini
and Balampanis, Konstantinos
Parissis, John
Andreadou, Ioanna
and Tsoumani, Maria
Chania, Christina
Katogiannis, Konstantinos
and Dimitriadis, George
Bamias, Aristotelis
Ikonomidis, Ignatios
Περιοδικό:
Free Radicals and Antioxidants
Λέξεις-κλειδιά:
glucagon-like peptide-1 receptor agonists; sodium-glucose
cotransporter-2 inhibitors; Malondialdehyde; Thiobarbituric Acid
Reactive Substances;
2,2(SIC)-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) radical
DOI:
10.3390/antiox10091379
