Περίληψη:
BACKGROUND
Chronic heart failure (CHF) is a complex syndrome characterized by a
progressive reduction of the left ventricular (LV) contractility, low
exercise tolerance, and increased mortality and morbidity. Diastolic
dysfunction (DD) of the LV, is a keystone in the pathophysiology of CHF
and plays a major role in the progression of most cardiac diseases.
Also, it is well estimated that exercise training induces several
beneficial effects on patients with CHF.
AIM
To evaluate the impact of a cardiac rehabilitation program on the DD and
LV ejection fraction (EF) in patients with CHF.
METHODS
Thirty-two stable patients with CHF (age: 56 +/- 10 years, EF: 32% +/-
8%, 88% men) participated in an exercise rehabilitation program. They
were randomly assigned statement: to aerobic exercise (AER) or combined
aerobic and strength training (COM), based on age and peak oxygen
uptake, as stratified randomization criteria. Before and after the
program, they underwent a symptom-limited maximal cardiopulmonary
exercise testing (CPET) and serial echocardiography evaluation to
evaluate peak oxygen uptake (VO2peak), peak workload (W-peak), DD grade,
right ventricular systolic pressure (RVSP), and EF.
RESULTS
The whole cohort improved VO2peak, and W-peak, as well as DD grade (P <
0.05). Overall, 9 patients (28.1%) improved DD grade, while 23 (71.9%)
remained at the same DD grade; this was a significant difference,
considering DD grade at baseline (P < 0.05). In addition, the whole
cohort improved RVSP and EF (P < 0.05). Not any between-group
differences were observed in the variables assessed (P > 0.05).
CONCLUSION
Exercise rehabilitation improves indices of diastolic and systolic
dysfunction. Exercise protocol was not observed to affect outcomes.
These results need to be further investigated in larger samples.
Συγγραφείς:
Chaveles, Ioannis
Papazachou, Ourania
Al Shamari, Manal and
Delis, Dimitrios
Ntalianis, Argirios
Panagopoulou, Niki and
Nanas, Serafim
Karatzanos, Eleftherios
